Universität zu Köln

Joaquim, Mariana and Escobar-Henriques, Mafalda ORCID: 0000-0002-0879-3119 (2020). Role of Mitofusins and Mitophagy in Life or Death Decisions. Front. Cell. Dev. Biol., 8. LAUSANNE: FRONTIERS MEDIA SA. ISSN 2296-634X

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Abstract

Mitochondria entail an incredible dynamism in their morphology, impacting death signaling and selective elimination of the damaged organelles. In turn, by recycling the superfluous or malfunctioning mitochondria, mostly prevalent during aging, mitophagy contributes to maintain a healthy mitochondrial network. Mitofusins locate at the outer mitochondrial membrane and control the plastic behavior of mitochondria, by mediating fusion events. Besides deciding on mitochondrial interconnectivity, mitofusin 2 regulates physical contacts between mitochondria and the endoplasmic reticulum, but also serves as a decisive docking platform for mitophagy and apoptosis effectors. Thus, mitofusins integrate multiple bidirectional inputs from and into mitochondria and ensure proper energetic and metabolic cellular performance. Here, we review the role of mitofusins and mitophagy at the cross-road between life and apoptotic death decisions. Furthermore, we highlight the impact of this interplay on disease, focusing on how mitofusin 2 and mitophagy affect non-alcoholic fatty liver disease.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Joaquim, Mariana UNSPECIFIED UNSPECIFIED UNSPECIFIED Escobar-Henriques, Mafalda UNSPECIFIED orcid.org/0000-0002-0879-3119 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-318598
DOI:	10.3389/fcell.2020.572182
Journal or Publication Title:	Front. Cell. Dev. Biol.
Volume:	8
Date:	2020
Publisher:	FRONTIERS MEDIA SA
Place of Publication:	LAUSANNE
ISSN:	2296-634X
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Biology > Institute for Genetics
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MARIE-TOOTH DISEASE; INTERVERTEBRAL DISC DEGENERATION; QUALITY-CONTROL MECHANISMS; FATTY LIVER-DISEASE; E3 UBIQUITIN LIGASE; MITOCHONDRIAL FUSION; ENDOPLASMIC-RETICULUM; SKELETAL-MUSCLE; CYTOCHROME-C; CELL-DEATH Multiple languages Cell Biology; Developmental Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/31859