Universität zu Köln

Bey, K., Weinhold, L., Gruetzmann, R., Heinzel, S., Kaufmann, C., Klawohn, J., Riesel, A., Lennertz, L., Schmid, M., Ramirez, A., Kathmann, N. and Wagner, M. (2020). The polygenic risk for obsessive-compulsive disorder is associated with the personality trait harm avoidance. Acta Psychiatr. Scand., 142 (4). S. 326 - 337. HOBOKEN: WILEY. ISSN 1600-0447

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Abstract

Objective Obsessive-compulsive disorder (OCD) is a complex psychiatric disorder with a substantial genetic contribution. While the specific variants underlying OCD's heritability are still unknown, findings from genome-wide association studies (GWAS) corroborate the importance of common SNPs explaining the phenotypic variance in OCD. Investigating associations between the genetic liability for OCD, as reflected by a polygenic risk score (PRS), and potential endophenotypes of the disorder, such as the personality trait harm avoidance, may aid the understanding of functional pathways from genes to diagnostic phenotypes. Methods We derived PRS for OCD at severalP-value thresholds based on the latest Psychiatric Genomics Consortium OCD GWAS (2688 cases, 7037 controls) in an independent sample of OCD patients (n = 180), their unaffected first-degree relatives (n = 108) and healthy controls (n = 200). Using linear regression, we tested whether these PRS are associated with the personality trait harm avoidance. Results Results showed that OCD PRS significantly predicted OCD status, with patients having the highest scores and relatives having intermediate scores. Furthermore, the genetic risk for OCD was associated with harm avoidance across the entire sample, and among OCD patients. As indicated by mediation analyses, harm avoidance mediated the association between the OCD PRS and OCD caseness. These results were observed at multipleP-value thresholds and persisted after the exclusion of patients with a current comorbid major depressive or anxiety disorder. Conclusion Our findings support the polygenic nature of OCD and further validate harm avoidance as a candidate endophenotype and diathesis of OCD.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Bey, K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Weinhold, L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gruetzmann, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Heinzel, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kaufmann, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Klawohn, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Riesel, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lennertz, L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmid, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ramirez, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kathmann, N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wagner, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-319861
DOI:	10.1111/acps.13226
Journal or Publication Title:	Acta Psychiatr. Scand.
Volume:	142
Number:	4
Page Range:	S. 326 - 337
Date:	2020
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1600-0447
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language GENOME-WIDE ASSOCIATION; SYMPTOM DIMENSIONS; ANXIETY DISORDERS; GERMAN VERSION; TEMPERAMENT; CLONINGERS; INVENTORY; CHARACTER; FAMILY; OCD Multiple languages Psychiatry Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/31986