Universität zu Köln

Battermann, Simone, Milzi, Andrea ORCID: 0000-0001-7580-8029, Dettori, Rosalia, Burgmaier, Kathrin, Marx, Nikolaus, Burgmaier, Mathias and Reith, Sebastian (2020). High cardiovascular risk of patients with type 2 diabetes is only partially attributed to angiographic burden of atherosclerosis. Diabetes Vasc. Dis. Res., 17 (5). LONDON: SAGE PUBLICATIONS LTD. ISSN 1752-8984

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Abstract

Background: Patients with type 2 diabetes (T2DM) are at high risk for cardiovascular events and present more severe coronary artery disease (CAD). The Gensini and COURAGE scores are established angiographic instruments to assess CAD severity, which may also predict future cardiovascular risk. However, it is unclear if these scores are able to depict the increased risk of patients with T2DM and stable CAD (T2DM-SAP). Methods: We performed quantitative coronary angiography and assessed the Gensini and COURAGE scores in 124 patients with T2DM-SAP. Angiographic data were compared to patients with stable angina without T2DM (Non-DM-SAP, n = 74), and to patients with acute coronary syndrome and T2DM (T2DM-ACS, n = 53). Results: T2DM-SAP patients had similar Gensini and COURAGE-scores compared to Non-DM-SAP-patients (Gensini: 14.44 +/- 27.34 vs 11.49 +/- 26.99, p = 0.465; COURAGE: 3.48 +/- 4.49 vs 3.60 +/- 4.72, p = 0.854). In contrast, T2DM-SAP patients had significantly lower Gensini (14.44 +/- 27.34 vs 30.94 +/- 48.74, p = 0.003) and lower COURAGE (3.48 +/- 4.49 vs 5.30 +/- 4.63, p = 0.016) scores compared to T2DM-ACS-patients. Conclusion: Both the Gensini and the COURAGE score fail to predict the high cardiovascular risk of patients with T2DM-SAP. Therefore, these scores should be used with caution in the assessment of future risk of patients with T2DM. However, among T2DM-ACS patients, both scores are increased, reflecting the high cardiovascular risk in this patient population.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Battermann, Simone UNSPECIFIED UNSPECIFIED UNSPECIFIED Milzi, Andrea UNSPECIFIED orcid.org/0000-0001-7580-8029 UNSPECIFIED Dettori, Rosalia UNSPECIFIED UNSPECIFIED UNSPECIFIED Burgmaier, Kathrin UNSPECIFIED UNSPECIFIED UNSPECIFIED Marx, Nikolaus UNSPECIFIED UNSPECIFIED UNSPECIFIED Burgmaier, Mathias UNSPECIFIED UNSPECIFIED UNSPECIFIED Reith, Sebastian UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-319999
DOI:	10.1177/1479164120953612
Journal or Publication Title:	Diabetes Vasc. Dis. Res.
Volume:	17
Number:	5
Date:	2020
Publisher:	SAGE PUBLICATIONS LTD
Place of Publication:	LONDON
ISSN:	1752-8984
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language Endocrinology & Metabolism; Peripheral Vascular Disease Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/31999