Universität zu Köln

Laursen, Christian B. ORCID: 0000-0001-6382-9906, Davidsen, Jesper Romhild ORCID: 0000-0003-4128-4014, Van Acker, Lander, Salzer, Helmut J. F., Seidel, Danila, Cornely, Oliver A., Hoenigl, Martin ORCID: 0000-0002-1653-2824, Alastruey-Izquierdo, Ana ORCID: 0000-0001-8651-4405, Hennequin, Christophe, Godet, Cendrine, Barac, Aleksandra, Flick, Holger, Munteanu, Oxana and Van Braeckel, Eva ORCID: 0000-0002-7242-0747 (2020). CPAnet Registry-An International Chronic Pulmonary Aspergillosis Registry. J. Fungi, 6 (3). BASEL: MDPI. ISSN 2309-608X

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Abstract

Chronic pulmonary aspergillosis (CPA) is a chronic fungal infection of the lung associated with high morbidity and mortality. The CPA Research network (CPAnet) registry established in 2018 is an international multicenter collaboration aiming to improve CPA knowledge and patient care. This study's aim was to describe the data collection process and content of CPAnet registry with preliminary clinical data. In the CPAnet registry, clinical data are collected through a web-based questionnaire. Data include CPA phenotype, comorbidities, treatment, outcome, and follow-up from several international centers. An exemplary descriptive analysis was performed on 74 patients, who were registered online before April 2020. CPA patients were predominantly (72%) male, 39% had chronic obstructive pulmonary disease, and 68% had a history of smoking. Chronic cavitary pulmonary aspergillosis was the most common CPA subtype (62%). In 32 patients (52%), voriconazole was the preferred first-line therapy. The multicenter multinational CPAnet registry is a valuable approach to gather comprehensive data on a large study population and reflects real-world clinical practice rather than focusing on specific patient populations in more specialized centers. Additional CPA reference centers are being encouraged to join this promising clinical research collaboration.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Laursen, Christian B. UNSPECIFIED orcid.org/0000-0001-6382-9906 UNSPECIFIED Davidsen, Jesper Romhild UNSPECIFIED orcid.org/0000-0003-4128-4014 UNSPECIFIED Van Acker, Lander UNSPECIFIED UNSPECIFIED UNSPECIFIED Salzer, Helmut J. F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Seidel, Danila UNSPECIFIED UNSPECIFIED UNSPECIFIED Cornely, Oliver A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoenigl, Martin UNSPECIFIED orcid.org/0000-0002-1653-2824 UNSPECIFIED Alastruey-Izquierdo, Ana UNSPECIFIED orcid.org/0000-0001-8651-4405 UNSPECIFIED Hennequin, Christophe UNSPECIFIED UNSPECIFIED UNSPECIFIED Godet, Cendrine UNSPECIFIED UNSPECIFIED UNSPECIFIED Barac, Aleksandra UNSPECIFIED UNSPECIFIED UNSPECIFIED Flick, Holger UNSPECIFIED UNSPECIFIED UNSPECIFIED Munteanu, Oxana UNSPECIFIED UNSPECIFIED UNSPECIFIED Van Braeckel, Eva UNSPECIFIED orcid.org/0000-0002-7242-0747 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-320225
DOI:	10.3390/jof6030096
Journal or Publication Title:	J. Fungi
Volume:	6
Number:	3
Date:	2020
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2309-608X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language GLOBAL BURDEN; GUIDELINES; DIAGNOSIS; UPDATE Multiple languages Microbiology; Mycology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/32022