Universität zu Köln

Marnitz, Simone, Walter, Till, Schoemig-Markiefka, Birgid, Engler, Tobias, Kommoss, Stefan and Brucker, Sara Yvonne (2020). A Modern Approach to Endometrial Carcinoma: Will Molecular Classification Improve Precision Medicine in the Future? Cancers, 12 (9). BASEL: MDPI. ISSN 2072-6694

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Abstract

Simple Summary The scientific community widely agrees that molecular classification will be key to endometrial carcinoma therapeutic strategies in the future. Retrospective analyses of large endometrial carcinoma patient cohorts gave rise to a new understanding of one of the most relevant gynecologic malignancies. Potentially replacing the current type I and type II terminology, four molecular subtypes have been established, each of them reflecting underlying molecular aberrations and distinct clinical behavior. Future research will have to focus on how to integrate these new findings into clinical practice with the ultimate goal to drive personalized endometrial carcinoma patient care forward. Endometrial cancer has been histologically classified as either an estrogen-dependent cancer with a favorable outcome or an estrogen-independent cancer with a worse prognosis. These parameters, along with the clinical attributions, have been the basis for risk stratification. Recent molecular and histopathological findings have suggested a more complex approach to risk stratification. Findings from the Cancer Genome Atlas Research Network established four distinctive genomic groups: ultramutated, hypermutated, copy-number low and copy-number high prognostic subtypes. Subsequently, more molecular and histopathologic classifiers were evaluated for their prognostic and predictive value. The impact of molecular classification is evident and will be recognized by the upcoming WHO classification. Further research is needed to give rise to a new era of molecular-based endometrial carcinoma patient care.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Marnitz, Simone UNSPECIFIED UNSPECIFIED UNSPECIFIED Walter, Till UNSPECIFIED UNSPECIFIED UNSPECIFIED Schoemig-Markiefka, Birgid UNSPECIFIED UNSPECIFIED UNSPECIFIED Engler, Tobias UNSPECIFIED UNSPECIFIED UNSPECIFIED Kommoss, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Brucker, Sara Yvonne UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-320231
DOI:	10.3390/cancers12092577
Journal or Publication Title:	Cancers
Volume:	12
Number:	9
Date:	2020
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2072-6694
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PHASE-III TRIAL; ESTRO CONSENSUS CONFERENCE; STAGE-I; ADJUVANT CHEMORADIOTHERAPY; INTERMEDIATE-RISK; RADIATION-THERAPY; L1CAM EXPRESSION; GRADING SYSTEMS; CANCER PORTEC-3; ASTEC TRIAL Multiple languages Oncology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/32023