Universität zu Köln

Rieder, Marina, Laumann, Rosmarie, Witsch, Thilo, Schanze, Nancy, Heger, Lukas, Olivier, Christoph B., von zur Muehlen, Constantin, Bode, Christoph, Ahrens, Ingo, Lother, Achim, Duerschmied, Daniel ORCID: 0000-0001-5249-4012 and Hortmann, Marcus (2020). Evaluation of Serum Serotonin as a Biomarker for Myocardial Infarction and Ischemia/Reperfusion Injury. Appl. Sci.-Basel, 10 (18). BASEL: MDPI. ISSN 2076-3417

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Abstract

Background: Activated platelets release serotonin during acute myocardial infarction (AMI), aggravating myocardial damage and ischemia/reperfusion (I/R) injury. However, serum serotonin and its potential role as a biomarker for myocardial infarction and I/R injury have not been studied so far. Methods: In this investigator-initiated pilot study, we examined 38 patients with ST-segment myocardial infarction (STEMI). We determined serum serotonin levels prior to percutaneous coronary intervention and 8, 16, and 24 h afterwards. We studied whether serum serotonin was associated with I/R injury assessed by ECG analysis and by analysis of TIMI myocardial perfusion grade (TMP) and myocardial blush grade (MGB). Serum serotonin levels were compared to an age-matched control group consisting of patients admitted to the emergency department for any other reason than STEMI. Results: Serum serotonin levels were not elevated in the myocardial infarction group compared to the control cohort and they did not show any timeline kinetics after STEMI. They were not associated with the severity of coronary artery disease, the outcome of coronary angiography, the extent of I/R injury, or the degree of heart failure. Conclusions: Serum serotonin is not suitable as a biomarker after myocardial infarction and in the assessment of I/R injury.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Rieder, Marina UNSPECIFIED UNSPECIFIED UNSPECIFIED Laumann, Rosmarie UNSPECIFIED UNSPECIFIED UNSPECIFIED Witsch, Thilo UNSPECIFIED UNSPECIFIED UNSPECIFIED Schanze, Nancy UNSPECIFIED UNSPECIFIED UNSPECIFIED Heger, Lukas UNSPECIFIED UNSPECIFIED UNSPECIFIED Olivier, Christoph B. UNSPECIFIED UNSPECIFIED UNSPECIFIED von zur Muehlen, Constantin UNSPECIFIED UNSPECIFIED UNSPECIFIED Bode, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Ahrens, Ingo UNSPECIFIED UNSPECIFIED UNSPECIFIED Lother, Achim UNSPECIFIED UNSPECIFIED UNSPECIFIED Duerschmied, Daniel UNSPECIFIED orcid.org/0000-0001-5249-4012 UNSPECIFIED Hortmann, Marcus UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-320257
DOI:	10.3390/app10186379
Journal or Publication Title:	Appl. Sci.-Basel
Volume:	10
Number:	18
Date:	2020
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2076-3417
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ST-SEGMENT ELEVATION; ISCHEMIA-REPERFUSION INJURY; 5-HYDROXYTRYPTAMINE; PROTECTION; PERFUSION; RECOVERY; GRADE Multiple languages Chemistry, Multidisciplinary; Engineering, Multidisciplinary; Materials Science, Multidisciplinary; Physics, Applied Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/32025