Universität zu Köln

Escobar-Henriques, Mafalda ORCID: 0000-0002-0879-3119 and Anton, Vincent ORCID: 0000-0003-3008-6346 (2020). Mitochondrial Surveillance by Cdc48/p97: MAD vs. Membrane Fusion. Int. J. Mol. Sci., 21 (18). BASEL: MDPI. ISSN 1422-0067

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Abstract

Cdc48/p97 is a ring-shaped, ATP-driven hexameric motor, essential for cellular viability. It specifically unfolds and extracts ubiquitylated proteins from membranes or protein complexes, mostly targeting them for proteolytic degradation by the proteasome. Cdc48/p97 is involved in a multitude of cellular processes, reaching from cell cycle regulation to signal transduction, also participating in growth or death decisions. The role of Cdc48/p97 in endoplasmic reticulum-associated degradation (ERAD), where it extracts proteins targeted for degradation from the ER membrane, has been extensively described. Here, we present the roles of Cdc48/p97 in mitochondrial regulation. We discuss mitochondrial quality control surveillance by Cdc48/p97 in mitochondrial-associated degradation (MAD), highlighting the potential pathologic significance thereof. Furthermore, we present the current knowledge of how Cdc48/p97 regulates mitofusin activity in outer membrane fusion and how this may impact on neurodegeneration.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Escobar-Henriques, Mafalda UNSPECIFIED orcid.org/0000-0002-0879-3119 UNSPECIFIED Anton, Vincent UNSPECIFIED orcid.org/0000-0003-3008-6346 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-320330
DOI:	10.3390/ijms21186841
Journal or Publication Title:	Int. J. Mol. Sci.
Volume:	21
Number:	18
Date:	2020
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	1422-0067
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Biology > Institute for Genetics
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language UBIQUITIN-PROTEASOME SYSTEM; AAA-ATPASE P97; QUALITY-CONTROL; VMS1 TRANSLOCATION; STRUCTURAL BASIS; GTP HYDROLYSIS; MITOFUSIN FZO1; VCP MUTATIONS; PROTEIN; ER Multiple languages Biochemistry & Molecular Biology; Chemistry, Multidisciplinary Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/32033