Universität zu Köln

Hofmann, Kay ORCID: 0000-0002-2289-9083 (2020). The Evolutionary Origins of Programmed Cell Death Signaling. Cold Spring Harbor Perspect. Biol., 12 (9). COLD SPRING HARBOR: COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT. ISSN 1943-0264

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Abstract

Programmed cell death (PCD) pathways are found in many phyla, ranging from developmentally programmed apoptosis in animals to cell-autonomous programmed necrosis pathways that limit the spread of biotrophic pathogens in multicellular assemblies. Prominent examples for the latter include animal necroptosis and pyroptosis, plant hypersensitive response (HR), and fungal heterokaryon incompatibility (HI) pathways. PCD pathways in the different kingdoms show fundamental differences in execution mechanism, morphology of the dying cells, and in the biological sequelae. Nevertheless, recent studies have revealed remarkable evolutionary parallels, including a striking sequence relationship between the HeLo domains found in the pore-forming components of necroptosis and some types of plant HR and fungal HI pathways. Other PCD execution components show cross-kingdom conservation as well, or are derived from prokaryotic ancestors. The currently available data suggest a model, wherein the primordial eukaryotic PCD pathway used proteins similar to present-day plant R-proteins and caused necrotic cell death by direct action of Toll and IL-1 receptor (TIR) and HeLo-like domains.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hofmann, Kay UNSPECIFIED orcid.org/0000-0002-2289-9083 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-321497
DOI:	10.1101/cshperspect.a036442
Journal or Publication Title:	Cold Spring Harbor Perspect. Biol.
Volume:	12
Number:	9
Date:	2020
Publisher:	COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
Place of Publication:	COLD SPRING HARBOR
ISSN:	1943-0264
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Biology > Institute for Genetics
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MOLECULAR-MECHANISMS; CRYSTAL-STRUCTURE; SELF-ASSOCIATION; STRUCTURAL BASIS; DOMAIN REVEALS; APOPTOSIS; TIR; INFLAMMASOMES; NECROPTOSIS; PYROPTOSIS Multiple languages Cell Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/32149