Universität zu Köln

Mirrahimi, Mehri, Beik, Jaber, Mirrahimi, Mehraban, Alamzadeh, Zahra, Teymouri, Samaneh, Mahabadi, Vahid Pirhajati, Eslahi, Neda, Tazehmahalleh, Fatemeh Ebrahimi, Ghaznavi, Habib, Shakeri-Zadeh, Ali and Moustakis, Christos (2020). Triple combination of heat, drug and radiation using alginate hydrogel co-loaded with gold nanoparticles and cisplatin for locally synergistic cancer therapy. Int. J. Biol. Macromol., 158. S. 617 - 627. AMSTERDAM: ELSEVIER. ISSN 1879-0003

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Abstract

Although multimodal cancer therapy has shown superior antitumor efficacy in comparison to individual therapy due to the potential generation of synergistic interactions among the treatments, its clinical usage is highly hampered by systemic dose-limiting toxicities. Herein, we developed a multi-responsive nanocomplex constructed from alginate hydrogel co-loaded with cisplatin and gold nanoparticles (AuNPs) (abbreviated as ACA) to combine chemotherapy, radiotherapy (RT) and photothermal therapy. The nanocomplex markedly improved the efficiency of drug delivery where ACA resulted in noticeably higher tumor growth inhibition than free cisplatin. The tumor treated with ACA showed an increased heating rate upon 532 nm laser irradiation, indicating the photothermal conversion ability of the nanocomplex. While RT alone resulted in slight tumor growth inhibition, thermo-chemo therapy, chemoradiation therapy and thermo-radio therapy using ACA dramatically slowed down the rate of tumor growth. Upon 532 nm laser and 6 MV X-ray, the nanocomplex could enable a trimodal thermo-chemo-radio therapy that yielded complete tumor regression with no evidence of relapse during the 90-days follow up period. The results of this study demonstrated that the incorporation of AuNPs and cisplatin into alginate hydrogel network can effectively combine chemotherapy, RT and photothermal therapy to achieve a locally synergistic cancer therapy. (C) 2020 Elsevier B.V. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Mirrahimi, Mehri UNSPECIFIED UNSPECIFIED UNSPECIFIED Beik, Jaber UNSPECIFIED UNSPECIFIED UNSPECIFIED Mirrahimi, Mehraban UNSPECIFIED UNSPECIFIED UNSPECIFIED Alamzadeh, Zahra UNSPECIFIED UNSPECIFIED UNSPECIFIED Teymouri, Samaneh UNSPECIFIED UNSPECIFIED UNSPECIFIED Mahabadi, Vahid Pirhajati UNSPECIFIED UNSPECIFIED UNSPECIFIED Eslahi, Neda UNSPECIFIED UNSPECIFIED UNSPECIFIED Tazehmahalleh, Fatemeh Ebrahimi UNSPECIFIED UNSPECIFIED UNSPECIFIED Ghaznavi, Habib UNSPECIFIED UNSPECIFIED UNSPECIFIED Shakeri-Zadeh, Ali UNSPECIFIED UNSPECIFIED UNSPECIFIED Moustakis, Christos UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-321899
DOI:	10.1016/j.ijbiomac.2020.04.272
Journal or Publication Title:	Int. J. Biol. Macromol.
Volume:	158
Page Range:	S. 617 - 627
Date:	2020
Publisher:	ELSEVIER
Place of Publication:	AMSTERDAM
ISSN:	1879-0003
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HYPERTHERMIA; CHEMOTHERAPY; RADIOTHERAPY; RADIOSENSITIZATION; RESISTANCE; DELIVERY; NANOCOMPOSITE; OPPORTUNITIES; NANOCARRIERS; HYPOXIA Multiple languages Biochemistry & Molecular Biology; Chemistry, Applied; Polymer Science Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/32189