Universität zu Köln

Schennach, Rebecca, Riedel, Michael, Obermeier, Michael, Jaeger, Markus, Schmauss, Max, Laux, Gerd, Pfeiffer, Herbert, Naber, Dieter, Schmidt, Lutz G., Gaebel, Wolfgang, Klosterkoetter, Joachim, Heuser, Isabella, Maier, Wolfgang, Lemke, Matthias R., Ruether, Eckart, Klingberg, Stefan ORCID: 0000-0001-8081-7181, Gastpar, Markus, Seemueller, Florian, Spellmann, Ilja, Musil, Richard and Moeller, Hans-Juergen (2020). What happens with schizophrenia patients after their discharge from hospital? Results on outcome and treatment from a real-world 2-year follow-up trial. Eur. Arch. Psych. Clin. Neurosci., 270 (6). S. 661 - 672. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1433-8491

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Abstract

Aim of the study was to examine the course of schizophrenia patients within 2 years after discharge. Within a multicenter study of the German Competence Network on Schizophrenia, patients suffering from a schizophrenia spectrum disorder were examined regarding their psychopathological improvement, tolerability, and the treatment regime applied during hospitalization and a 2-year follow-up period. Response, remission, the level of everyday functioning, and relapse were furthermore evaluated during the follow-up period using established definitions for these outcome domains. The psychopharmacological treatment was specifically evaluated in terms of a potential association with relapse. 149 patients were available for analysis, with 65% of the patients being in response, 52% in symptomatic remission, and 64% having a satisfiable everyday functioning 2 years after their discharge from hospital. Despite these favorable outcome rates, 63% of the patients suffered from a relapse within the 2-year follow-up period with 86% of these patients being rehospitalized. Discharge non-responder and non-remitter were twice as likely to relapse during follow-up. A significant decrease of side-effects was observed with negligible rates of extrapyramidal side-effects, sedation, and weight gain during follow-up. Patients receiving treatment with atypical antipsychotics were found to have the lowest risk to relapse (p < 0.0001). The results highlight the natural and unsteady course of schizophrenia in most patients underlining the need to develop more specific treatment strategies ensuring ongoing stability and preventing relapse.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schennach, Rebecca UNSPECIFIED UNSPECIFIED UNSPECIFIED Riedel, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Obermeier, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Jaeger, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmauss, Max UNSPECIFIED UNSPECIFIED UNSPECIFIED Laux, Gerd UNSPECIFIED UNSPECIFIED UNSPECIFIED Pfeiffer, Herbert UNSPECIFIED UNSPECIFIED UNSPECIFIED Naber, Dieter UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmidt, Lutz G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gaebel, Wolfgang UNSPECIFIED UNSPECIFIED UNSPECIFIED Klosterkoetter, Joachim UNSPECIFIED UNSPECIFIED UNSPECIFIED Heuser, Isabella UNSPECIFIED UNSPECIFIED UNSPECIFIED Maier, Wolfgang UNSPECIFIED UNSPECIFIED UNSPECIFIED Lemke, Matthias R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ruether, Eckart UNSPECIFIED UNSPECIFIED UNSPECIFIED Klingberg, Stefan UNSPECIFIED orcid.org/0000-0001-8081-7181 UNSPECIFIED Gastpar, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED Seemueller, Florian UNSPECIFIED UNSPECIFIED UNSPECIFIED Spellmann, Ilja UNSPECIFIED UNSPECIFIED UNSPECIFIED Musil, Richard UNSPECIFIED UNSPECIFIED UNSPECIFIED Moeller, Hans-Juergen UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-322153
DOI:	10.1007/s00406-019-01055-4
Journal or Publication Title:	Eur. Arch. Psych. Clin. Neurosci.
Volume:	270
Number:	6
Page Range:	S. 661 - 672
Date:	2020
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1433-8491
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language REHOSPITALIZATION RATES; CLINICAL-TRIALS; REMISSION; RELAPSE; SCALE; RECOMMENDATIONS; DEFINITIONS; OUTPATIENTS; RISPERIDONE; PREDICTORS Multiple languages Clinical Neurology; Psychiatry Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/32215