Universität zu Köln

Marcordes, Sandra, Lueders, Imke, Grund, Lisa, Sliwa, Alexander, Maurer, Florian P., Hillemann, Doris, Mobius, Petra and Barth, Stefanie A. . Clinical outcome and diagnostic methods of atypical mycobacteriosis due toMycobacterium aviumssp.hominissuisin a group of captive lowland tapirs (Tapirus terrestris). Transbound. Emerg. Dis.. HOBOKEN: WILEY. ISSN 1865-1682

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Abstract

Tapirs seem particularly susceptible to mycobacterial infections, especially to tuberculosis caused byM. tuberculosisorM. bovis. In this case series, we report an infection with the non-tuberculous mycobacteria (NTM) speciesM. aviumssp.hominissuis(MAH) in a group of four (2.2) captive lowland tapirs (Tapirus terrestris). Two female tapirs showed mild respiratory signs such as coughing and mucous sputum production for several years, one juvenile male tapir had to be euthanized due to severe dyspnoea, and the adult male only showed mild respiratory signs in 2010. Post-mortem histopathology of the euthanized animal revealed a chronic bronchopneumonia, and MAH was detected via culture. Subsequently, the three remaining tapirs were tested further: serologically, the tapirs had high antibody titres againstM. avium, but they showed no reaction in the comparative skin test (TST). At several time points, the animals were tested for the presence of mycobacteria in different sample matrices including sputum samples, pooled faecal samples as well as swabs from the tapir enclosure to identify potential environmental niches of the pathogen. Moreover, animals were directly sampled using nasal swabs, endoscopic broncho-alveolar (BAL) and gastric lavages. MAH was detected by culture in the sputum samples, in the BAL of the breeding pair, as well as in the swimming pool water and walls, and in swabs taken from the tapir's sleeping beds. We conclude that the TST is not a useful diagnostic tool to detect MAC infections in tapirs, whereas antibody ELISA and culture from BAL appear more sensitive.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Marcordes, Sandra UNSPECIFIED UNSPECIFIED UNSPECIFIED Lueders, Imke UNSPECIFIED UNSPECIFIED UNSPECIFIED Grund, Lisa UNSPECIFIED UNSPECIFIED UNSPECIFIED Sliwa, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Maurer, Florian P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hillemann, Doris UNSPECIFIED UNSPECIFIED UNSPECIFIED Mobius, Petra UNSPECIFIED UNSPECIFIED UNSPECIFIED Barth, Stefanie A. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-322407
DOI:	10.1111/tbed.13786
Journal or Publication Title:	Transbound. Emerg. Dis.
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1865-1682
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language AVIUM SUBSP PARATUBERCULOSIS; BRONCHOALVEOLAR LAVAGE; HOMINISSUIS INFECTION; TUBERCULOSIS; IDENTIFICATION; STRAIN; TRANSMISSION; IS1245; ZOO Multiple languages Infectious Diseases; Veterinary Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/32240