Universität zu Köln

Angermann, Christiane E., Assmus, Birgit, Anker, Stefan D., Asselbergs, Folkert W., Brachmann, Johannes, Brett, Marie-Elena, Brugts, Jasper J., Ertl, Georg, Ginn, Greg, Hilker, Lutz, Koehler, Friedrich, Rosenkranz, Stephan, Zhou, Qian, Adamson, Philip B. and Boehm, Michael (2020). Pulmonary artery pressure-guided therapy in ambulatory patients with symptomatic heart failure: theCardioMEMS EuropeanMonitoringStudy forHeartFailure (MEMS-HF). Eur. J. Heart Fail., 22 (10). S. 1891 - 1902. HOBOKEN: WILEY. ISSN 1879-0844

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Abstract

Aims Heart failure (HF) leads to repeat hospitalisations and reduces the duration and quality of life. Pulmonary artery pressure (PAP)-guided HF management using the CardioMEMS (TM) HF system was shown to be safe and reduce HF hospitalisation (HFH) rates in New York Heart Association (NYHA) class III patients. However, these findings have not been replicated in health systems outside the United States. Therefore, the CardioMEMS European Monitoring Study for Heart Failure (MEMS-HF) evaluated the safety, feasibility, and performance of this device in Germany, The Netherlands, and Ireland. Methods and results A total of 234 NYHA class III patients (68 +/- 11 years, 22% female, >= 1 HFH in the preceding year) from 31 centres were implanted with a CardioMEMS sensor and underwent PAP-guided HF management. One-year rates of freedom from device- or system-related complications and from sensor failure (co-primary outcomes) were 98.3% [95% confidence interval (CI) 95.8-100.0] and 99.6% (95% CI 97.6-100.0), respectively. Survival rate was 86.2%. For the 12 months post- vs. pre-implant, HFHs decreased by 62% (0.60 vs. 1.55 events/patient-year; hazard ratio 0.38, 95% CI 0.31-0.48;P < 0.0001). After 12 months, mean PAP decreased by 5.1 +/- 7.4 mmHg, Kansas City Cardiomyopathy Questionnaire (KCCQ) overall/clinical summary scores increased from 47.0 +/- 24.0/51.2 +/- 24.8 to 60.5 +/- 24.3/62.4 +/- 24.1 (P < 0.0001), and the 9-item Patient Health Questionnaire sum score improved from 8.7 +/- 5.9 to 6.3 +/- 5.1 (P < 0.0001). Conclusion Haemodynamic-guided HF management proved feasible and safe in the health systems of Germany, The Netherlands, and Ireland. Physician-directed treatment modifications based on remotely obtained PAP values were associated with fewer HFH, sustainable PAP decreases, marked KCCQ improvements, and remission of depressive symptoms.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Angermann, Christiane E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Assmus, Birgit UNSPECIFIED UNSPECIFIED UNSPECIFIED Anker, Stefan D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Asselbergs, Folkert W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Brachmann, Johannes UNSPECIFIED UNSPECIFIED UNSPECIFIED Brett, Marie-Elena UNSPECIFIED UNSPECIFIED UNSPECIFIED Brugts, Jasper J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ertl, Georg UNSPECIFIED UNSPECIFIED UNSPECIFIED Ginn, Greg UNSPECIFIED UNSPECIFIED UNSPECIFIED Hilker, Lutz UNSPECIFIED UNSPECIFIED UNSPECIFIED Koehler, Friedrich UNSPECIFIED UNSPECIFIED UNSPECIFIED Rosenkranz, Stephan UNSPECIFIED UNSPECIFIED UNSPECIFIED Zhou, Qian UNSPECIFIED UNSPECIFIED UNSPECIFIED Adamson, Philip B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Boehm, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-323622
DOI:	10.1002/ejhf.1943
Journal or Publication Title:	Eur. J. Heart Fail.
Volume:	22
Number:	10
Page Range:	S. 1891 - 1902
Date:	2020
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1879-0844
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language QUALITY-OF-LIFE; HEALTH-STATUS; MANAGEMENT; MORTALITY; HOSPITALIZATIONS; QUESTIONNAIRE Multiple languages Cardiac & Cardiovascular Systems Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/32362