Schoen, Michael P., Berking, Carola, Biedermann, Tilo, Buhl, Timo, Erpenbeck, Luise, Eyerich, Kilian, Eyerich, Stefanie, Ghoreschi, Kamran, Goebeler, Matthias, Ludwig, Ralf J., Schaekel, Knut, Schilling, Bastian ORCID: 0000-0001-8859-4103, Schlapbach, Christoph ORCID: 0000-0003-0258-1243, Stary, Georg, von Stebut, Esther and Steinbrink, Kerstin . COVID-19 and immunological regulations - from basic and translational aspects to clinical implications. J. Dtsch. Dermatol. Ges.. HOBOKEN: WILEY. ISSN 1610-0387

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Abstract

The COVID-19 pandemic caused by SARS-CoV-2 has far-reaching direct and indirect medical consequences. These include both the course and treatment of diseases. It is becoming increasingly clear that infections with SARS-CoV-2 can cause considerable immunological alterations, which particularly also affect pathogenetically and/or therapeutically relevant factors. Against this background we summarize here the current state of knowledge on the interaction of SARS-CoV-2/COVID-19 with mediators of the acute phase of inflammation (TNF, IL-1, IL-6), type 1 and type 17 immune responses (IL-12, IL-23, IL-17, IL-36), type 2 immune reactions (IL-4, IL-13, IL-5, IL-31, IgE), B-cell immunity, checkpoint regulators (PD-1, PD-L1, CTLA4), and orally druggable signaling pathways (JAK, PDE4, calcineurin). In addition, we discuss in this context non-specific immune modulation by glucocorticosteroids, methotrexate, antimalarial drugs, azathioprine, dapsone, mycophenolate mofetil and fumaric acid esters, as well as neutrophil granulocyte-mediated innate immune mechanisms. From these recent findings we derive possible implications for the therapeutic modulation of said immunological mechanisms in connection with SARS-CoV-2/COVID-19. Although, of course, the greatest care should be taken with patients with immunologically mediated diseases or immunomodulating therapies, it appears that many treatments can also be carried out during the COVID-19 pandemic; some even appear to alleviate COVID-19.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Schoen, Michael P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Berking, CarolaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Biedermann, TiloUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Buhl, TimoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Erpenbeck, LuiseUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eyerich, KilianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eyerich, StefanieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ghoreschi, KamranUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Goebeler, MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ludwig, Ralf J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schaekel, KnutUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schilling, BastianUNSPECIFIEDorcid.org/0000-0001-8859-4103UNSPECIFIED
Schlapbach, ChristophUNSPECIFIEDorcid.org/0000-0003-0258-1243UNSPECIFIED
Stary, GeorgUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
von Stebut, EstherUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Steinbrink, KerstinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-323848
DOI: 10.1111/ddg.14169
Journal or Publication Title: J. Dtsch. Dermatol. Ges.
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1610-0387
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
NEUTROPHIL EXTRACELLULAR TRAPS; CYTOKINE STORM; CHECKPOINT BLOCKADE; MYCOPHENOLIC-ACID; CORONAVIRUS; CHLOROQUINE; PATHOGENESIS; INFECTIONS; THROMBOSIS; PNEUMONIAMultiple languages
DermatologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/32384

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