Universität zu Köln

Xiong, Yehui, Han, Zhifu and Chai, Jijie (2020). Resistosome and inflammasome: platforms mediating innate immunity. Curr. Opin. Plant Biol., 56. S. 47 - 56. LONDON: CURRENT BIOLOGY LTD. ISSN 1879-0356

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Abstract

The nucleotide-binding domain (NBD) and leucine-rich repeat (LRR) containing (NLR) proteins are intracellular immune receptors that sense pathogens or stress-associated signals in animals and plants. Direct or indirect binding of these stimuli to NLRs results in formation of higher-order large protein complexes termed inflammasomes in animals and resistosomes in plants to mediate immune signaling. Here we focus on plant NLRs and discuss the activation mechanism of the ZAR1 resistosome from Arabidopsis thaliana. We also outline the analogies and differences between the ZAR1 resistosome and the NLR inflammasomes, and discuss how the structural and biochemical information available on these two large types of protein complexes sheds light on signaling mechanisms of other plant NLRs.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Xiong, Yehui UNSPECIFIED UNSPECIFIED UNSPECIFIED Han, Zhifu UNSPECIFIED UNSPECIFIED UNSPECIFIED Chai, Jijie UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-324194
DOI:	10.1016/j.pbi.2020.03.010
Journal or Publication Title:	Curr. Opin. Plant Biol.
Volume:	56
Page Range:	S. 47 - 56
Date:	2020
Publisher:	CURRENT BIOLOGY LTD
Place of Publication:	LONDON
ISSN:	1879-0356
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Chemistry > Institute of Biochemistry
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NB-LRR PROTEIN; CELL-DEATH; RESISTANCE PROTEIN; NUCLEOTIDE-BINDING; STRUCTURAL BASIS; CRYSTAL-STRUCTURE; SELF-ASSOCIATION; RUST RESISTANCE; PATHOGEN EFFECTOR; CYTOCHROME-C Multiple languages Plant Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/32419