Universität zu Köln

Allgoewer, Chantal, Kretz, Anna-Laura, von Karstedt, Silvia ORCID: 0000-0002-7816-5919, Wittau, Mathias, Henne-Bruns, Doris and Lemke, Johannes ORCID: 0000-0003-2142-6097 (2020). Friend or Foe: S100 Proteins in Cancer. Cancers, 12 (8). BASEL: MDPI. ISSN 2072-6694

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Abstract

S100 proteins are widely expressed small molecular EF-hand calcium-binding proteins of vertebrates, which are involved in numerous cellular processes, such as Ca(2+)homeostasis, proliferation, apoptosis, differentiation, and inflammation. Although the complex network of S100 signalling is by far not fully deciphered, several S100 family members could be linked to a variety of diseases, such as inflammatory disorders, neurological diseases, and also cancer. The research of the past decades revealed that S100 proteins play a crucial role in the development and progression of many cancer types, such as breast cancer, lung cancer, and melanoma. Hence, S100 family members have also been shown to be promising diagnostic markers and possible novel targets for therapy. However, the current knowledge of S100 proteins is limited and more attention to this unique group of proteins is needed. Therefore, this review article summarises S100 proteins and their relation in different cancer types, while also providing an overview of novel therapeutic strategies for targeting S100 proteins for cancer treatment.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Allgoewer, Chantal UNSPECIFIED UNSPECIFIED UNSPECIFIED Kretz, Anna-Laura UNSPECIFIED UNSPECIFIED UNSPECIFIED von Karstedt, Silvia UNSPECIFIED orcid.org/0000-0002-7816-5919 UNSPECIFIED Wittau, Mathias UNSPECIFIED UNSPECIFIED UNSPECIFIED Henne-Bruns, Doris UNSPECIFIED UNSPECIFIED UNSPECIFIED Lemke, Johannes UNSPECIFIED orcid.org/0000-0003-2142-6097 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-324217
DOI:	10.3390/cancers12082037
Journal or Publication Title:	Cancers
Volume:	12
Number:	8
Date:	2020
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2072-6694
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CALCIUM-BINDING PROTEIN; METASTASIS-ASSOCIATED PROTEIN; EPITHELIAL-MESENCHYMAL TRANSITION; HUMAN EPIDERMAL DIFFERENTIATION; S100A4-INDUCED CELL MOTILITY; PUTATIVE TUMOR-SUPPRESSOR; AMINO-ACID-SEQUENCE; PANCREATIC-CANCER; BREAST-CANCER; COLORECTAL-CANCER Multiple languages Oncology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/32421