Universität zu Köln

Erhardt, Johannes B., Lottner, Thomas ORCID: 0000-0003-3215-7582, Pasluosta, Cristian F., Gessner, Isabel ORCID: 0000-0001-9674-161X, Mathur, Sanjay, Schuettler, Martin, Bock, Michael ORCID: 0000-0001-9720-3506 and Stieglitz, Thomas ORCID: 0000-0002-7349-4254 (2020). Fabrication and validation of reference structures for the localization of subdural standard- and micro-electrodes in MRI. J. Neural Eng., 17 (4). BRISTOL: IOP PUBLISHING LTD. ISSN 1741-2552

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Abstract

Objective.Report simple reference structure fabrication and validate the precise localization of subdural micro- and standard electrodes in magnetic resonance imaging (MRI) in phantom experiments.Approach. Electrode contacts with diameters of 0.3 mm and 4 mm are localized in 1.5 T MRI using reference structures made of silicone and iron oxide nanoparticle doping. The precision of the localization procedure was assessed for several standard MRI sequences and implant orientations in phantom experiments and compared to common clinical localization procedures.Main results.A localization precision of 0.41 +/- 0.20 mm could be achieved for both electrode diameters compared to 1.46 +/- 0.69 mm that was achieved for 4 mm standard electrode contacts localized using a common clinical standard method. The new reference structures are intrinsically bio-compatible, and they can be detected with currently available feature detection software so that a clinical implementation of this technology should be feasible.Significance.Neuropathologies are increasingly diagnosed and treated with subdural electrodes, where the exact localization of the electrode contacts with respect to the patient's cortical anatomy is a prerequisite for the procedure. Post-implantation electrode localization using MRI may be advantageous compared to the common alternative of CT-MRI image co-registration, as it avoids systematic localization errors associated with the co-registration itself, as well as brain shift and implant movement. Additionally, MRI provides superior soft tissue contrast for the identification of brain lesions without exposing the patient to ionizing radiation. Recent studies show that smaller electrodes and high-density electrode grids are ideal for clinical and research purposes, but the localization of these devices in MRI has not been demonstrated.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Erhardt, Johannes B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lottner, Thomas UNSPECIFIED orcid.org/0000-0003-3215-7582 UNSPECIFIED Pasluosta, Cristian F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gessner, Isabel UNSPECIFIED orcid.org/0000-0001-9674-161X UNSPECIFIED Mathur, Sanjay UNSPECIFIED UNSPECIFIED UNSPECIFIED Schuettler, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Bock, Michael UNSPECIFIED orcid.org/0000-0001-9720-3506 UNSPECIFIED Stieglitz, Thomas UNSPECIFIED orcid.org/0000-0002-7349-4254 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-324366
DOI:	10.1088/1741-2552/abad7a
Journal or Publication Title:	J. Neural Eng.
Volume:	17
Number:	4
Date:	2020
Publisher:	IOP PUBLISHING LTD
Place of Publication:	BRISTOL
ISSN:	1741-2552
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Chemistry > Institute of Inorganic Chemistry
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language INTRACRANIAL ELECTRODES; CO-REGISTRATION; LARGE-SCALE; EPILEPSY; RESECTION; ARRAYS; SAFETY; CORTEX; DEPTH; STIMULATION Multiple languages Engineering, Biomedical; Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/32436