Neesgaard, Bastian, Mocroft, Amanda, Greenberg, Lauren, Larsen, Jakob Friis, Wandeler, Gilles, Zangerle, Robert, Gunthard, Huldrych, Smith, Colette ORCID: 0000-0003-2847-3355, De Wit, Stephane, Mussini, Cristina, Castagna, Antonella, Monforte, Antonella D'Arminio, Vehreschild, Joerg Janne, Wasmuth, Jan-Christian, Pradier, Christian, Chkhartishvili, Nikoloz, Wit, Ferdinand W. N. M., Law, Matthew, Sonnerborg, Anders, Bruguera, Andreau, Stephan, Christoph, Vannappagari, Vani, Haubrich, Richard, Kirk, Ole, Podlekareva, Daria ORCID: 0000-0003-3187-0597, Kowalska, Justyna, Raben, Dorthe, Rockstroh, Juergen, Peters, Lars, Parades, Roger, Grabmeier-Pfistershammer, Katharina, Scherrer, Alexandra, Johnson, Margaret, Necsoi, Coca, Borghi, Vanni, Muccini, Camilla ORCID: 0000-0002-0900-5639, Tserstvadze, Tengiz, Petoumenos, Kathy, Volny-Anne, Alain, Lundgren, Jens and Ryom, Lene (2020). How to RESPOND to Modern Challenges for People Living with HIV: A Profile for a New Cohort Consortium. Microorganisms, 8 (8). BASEL: MDPI. ISSN 2076-2607

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Abstract

Background: the International Cohort Consortium of Infectious Disease (RESPOND) is a collaboration dedicated to research on HIV and other infectious diseases. Methods: RESPOND is a flexible organization, with several independent substudies operating under one shared governance. HIV-related variables, including full antiretroviral therapy (ART) history, are collected annually for all participants and merged with substudy specific data into a shared data pool. Incident clinical events are reported using standardized forms. Prospective follow-up started 1/10/17 (enrolment) with retrospective data collected back to 01/01/12. Results: Overall, 17 cohorts from Europe and Australia provided data on 26,258 people living with HIV (PLWH). The majority (43.3%) of the population were white, with men-sex-with-men accounting for 43.3% of the risk for HIV acquisition. The median age was 48 years (IQR 40-56) and 5.2% and 25.5% were known to be co-infected with hepatitis B or C. While 5.3% were ART-naive, the median duration on ART was 10.1 years (4.8-17.6), with 89.5% having a VL <200 copies/mL and the median CD4 count being 621 cells/mu L (438-830). Malignancies (n= 361) and cardiovascular disease (n= 168) were the predominant reported clinical events. Conclusion: RESPOND's large, diverse study population and standardized clinical endpoints puts the consortium in a unique position to respond to the diverse modern challenges for PLWH.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Neesgaard, BastianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mocroft, AmandaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Greenberg, LaurenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Larsen, Jakob FriisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wandeler, GillesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zangerle, RobertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gunthard, HuldrychUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Smith, ColetteUNSPECIFIEDorcid.org/0000-0003-2847-3355UNSPECIFIED
De Wit, StephaneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mussini, CristinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Castagna, AntonellaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Monforte, Antonella D'ArminioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vehreschild, Joerg JanneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wasmuth, Jan-ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pradier, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chkhartishvili, NikolozUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wit, Ferdinand W. N. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Law, MatthewUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sonnerborg, AndersUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bruguera, AndreauUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stephan, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vannappagari, VaniUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Haubrich, RichardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kirk, OleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Podlekareva, DariaUNSPECIFIEDorcid.org/0000-0003-3187-0597UNSPECIFIED
Kowalska, JustynaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Raben, DortheUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rockstroh, JuergenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Peters, LarsUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Parades, RogerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Grabmeier-Pfistershammer, KatharinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Scherrer, AlexandraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Johnson, MargaretUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Necsoi, CocaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Borghi, VanniUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Muccini, CamillaUNSPECIFIEDorcid.org/0000-0002-0900-5639UNSPECIFIED
Tserstvadze, TengizUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Petoumenos, KathyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Volny-Anne, AlainUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lundgren, JensUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ryom, LeneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-324543
DOI: 10.3390/microorganisms8081164
Journal or Publication Title: Microorganisms
Volume: 8
Number: 8
Date: 2020
Publisher: MDPI
Place of Publication: BASEL
ISSN: 2076-2607
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
ANTIRETROVIRAL THERAPY; RISKMultiple languages
MicrobiologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/32454

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