Universität zu Köln

Leopold, Karolina, Bauer, Michael, Bechdolf, Andreas, Correll, Christoph U., Holtmann, Martin, Juckel, Georg, Lambert, Martin, Meyer, Thomas D., Pfeiffer, Steffi, Kittel-Schneider, Sarah ORCID: 0000-0003-3057-6150, Reif, Andreas, Stamm, Thomas J., Rottmann-Wolf, Maren, Mathiebe, Josephine, Kellmann, Eva L., Ritter, Philipp, Krueger-Oezguerdal, Seza, Karow, Anne, Sondergeld, Lene-Marie, Roessner, Veit ORCID: 0000-0002-1873-7081, Sauer, Cathrin and Pfennig, Andrea (2020). Efficacy of cognitive-behavioral group therapy in patients at risk for serious mental illness presenting with subthreshold bipolar symptoms: Results from a prespecified interim analysis of a multicenter, randomized, controlled study. Bipolar Disord., 22 (5). S. 517 - 530. HOBOKEN: WILEY. ISSN 1399-5618

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Abstract

Objective Most patients with bipolar disorders (BD) exhibit prodromal symptoms before a first (hypo)manic episode. Patients with clinically significant symptoms fulfilling at-risk criteria for serious mental illness (SMI) require effective and safe treatment. Cognitive-behavioral psychotherapy (CBT) has shown promising results in early stages of BD and in patients at high risk for psychosis. We aimed to investigate whether group CBT can improve symptoms and functional deficits in young patients at risk for SMI presenting with subthreshold bipolar symptoms. Method In a multicenter, randomized, controlled trial, patients at clinical risk for SMI presenting with subthreshold bipolar symptoms aged 15-30 years were randomized to 14 weeks of at-risk for BD-specific group CBT or unstructured group meetings. Primary efficacy endpoints were differences in affective symptomatology and psychosocial functioning at 14 weeks. At-risk status was defined as a combination of subthreshold bipolar symptomatology, reduction of psychosocial functioning and a family history for (schizo)affective disorders. A prespecified interim analysis was conducted at 75% of the targeted sample. Results Of 128 screened participants, 75 were randomized to group CBT (n = 38, completers = 65.8%) vs unstructured group meetings (n = 37, completers = 78.4%). Affective symptomatology and psychosocial functioning improved significantly at week 14 (P < .001) and during 6 months (P < .001) in both groups, without significant between-group differences. Findings are limited by the interim character of the analysis, the use of not fully validated early detection interviews, a newly adapted intervention manual, and the substantial drop-outs. Conclusions Results suggest that young patients at-risk for SMI presenting with subthreshold bipolar symptoms benefit from early group sessions. The degree of specificity and psychotherapeutic interaction needed requires clarification.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Leopold, Karolina UNSPECIFIED UNSPECIFIED UNSPECIFIED Bauer, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Bechdolf, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Correll, Christoph U. UNSPECIFIED UNSPECIFIED UNSPECIFIED Holtmann, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Juckel, Georg UNSPECIFIED UNSPECIFIED UNSPECIFIED Lambert, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Meyer, Thomas D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pfeiffer, Steffi UNSPECIFIED UNSPECIFIED UNSPECIFIED Kittel-Schneider, Sarah UNSPECIFIED orcid.org/0000-0003-3057-6150 UNSPECIFIED Reif, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Stamm, Thomas J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Rottmann-Wolf, Maren UNSPECIFIED UNSPECIFIED UNSPECIFIED Mathiebe, Josephine UNSPECIFIED UNSPECIFIED UNSPECIFIED Kellmann, Eva L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ritter, Philipp UNSPECIFIED UNSPECIFIED UNSPECIFIED Krueger-Oezguerdal, Seza UNSPECIFIED UNSPECIFIED UNSPECIFIED Karow, Anne UNSPECIFIED UNSPECIFIED UNSPECIFIED Sondergeld, Lene-Marie UNSPECIFIED UNSPECIFIED UNSPECIFIED Roessner, Veit UNSPECIFIED orcid.org/0000-0002-1873-7081 UNSPECIFIED Sauer, Cathrin UNSPECIFIED UNSPECIFIED UNSPECIFIED Pfennig, Andrea UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-324772
DOI:	10.1111/bdi.12894
Journal or Publication Title:	Bipolar Disord.
Volume:	22
Number:	5
Page Range:	S. 517 - 530
Date:	2020
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1399-5618
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language EARLY INTERVENTION; AT-RISK; PSYCHOTHERAPEUTIC INTERVENTIONS; PRODROMAL SYMPTOMS; ANXIETY DISORDERS; MOOD DISORDERS; RATING-SCALE; DOUBLE-BLIND; YOUTH; METAANALYSIS Multiple languages Clinical Neurology; Neurosciences; Psychiatry Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/32477