Universität zu Köln

Wuerdemann, Nora, Gultekin, Sibel E., Puetz, Katharina, Wittekindt, Claus, Huebbers, Christian U., Sharma, Shachi J., Eckel, Hans, Schubotz, Anna B., Gattenloehner, Stefan, Buettner, Reinhard, Speel, Ernst-Jan, Klussmann, Jens P., Wagner, Steffen and Quaas, Alexander (2020). PD-L1 Expression and a High Tumor Infiltrate of CD8+Lymphocytes Predict Outcome in Patients with Oropharyngeal Squamous Cells Carcinoma. Int. J. Mol. Sci., 21 (15). BASEL: MDPI. ISSN 1422-0067

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Abstract

Carcinogenesis of human papillomavirus (HPV)-related (+) oropharyngeal squamous cell carcinoma (OPSCC) differs from HPV-negative (-) OPSCC. HPV-related immune-escape-mechanism could be responsible for the development and progression of HPV+ tumors and an immunophenotype different from HPV- OPSCC is expected. The purpose of this study was to analyze the expression of programmed cell death protein 1 ligand 1 (PD-L1) and its prognostic relevance in relation to CD8+ tumor infiltrating lymphocytes (TILs) and the major histocompatibility complex (MHC) I expression in OPSCC. We quantified PD-L1 expression on tumor cells (TC) and macrophages and MHC I expression in association to CD8(+)TILs by immunohistochemistry on tissue microarray derived from 171 HPV+/-OPSCC. HPV-status was determined by p16(INK4a)immunohistochemistry/HPV-DNA detection. Presence of CD8(+)TILs, PD-L1 expression on TC, and a more frequent loss of MHC I in HPV+ compared to HPV- OPSCC was detected. A high amount of CD8(+)TILs in the whole cohort and in HPV+ OPSCC and PD-L1 expression on TC in HPV- OPSCC was associated with favorable overall survival. There was a trend for an improved outcome according to PD-L1 expression (macrophages) in HPV+ OPSCC without reaching statistical significance. CD8(+)TILs and PD-L1-expression have prognostic impact in OPSCC and might present useful biomarkers for predicting clinical outcome and personalized therapy concepts.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Wuerdemann, Nora UNSPECIFIED UNSPECIFIED UNSPECIFIED Gultekin, Sibel E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Puetz, Katharina UNSPECIFIED UNSPECIFIED UNSPECIFIED Wittekindt, Claus UNSPECIFIED UNSPECIFIED UNSPECIFIED Huebbers, Christian U. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sharma, Shachi J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Eckel, Hans UNSPECIFIED UNSPECIFIED UNSPECIFIED Schubotz, Anna B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gattenloehner, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Buettner, Reinhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Speel, Ernst-Jan UNSPECIFIED UNSPECIFIED UNSPECIFIED Klussmann, Jens P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wagner, Steffen UNSPECIFIED UNSPECIFIED UNSPECIFIED Quaas, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-324890
DOI:	10.3390/ijms21155228
Journal or Publication Title:	Int. J. Mol. Sci.
Volume:	21
Number:	15
Date:	2020
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	1422-0067
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HLA CLASS-I; HPV-ASSOCIATED HEAD; MHC CLASS-I; HUMAN-PAPILLOMAVIRUS; PROGNOSTIC BIOMARKER; T-CELLS; DOWN-REGULATION; NECK; ASSOCIATION; PROTEIN Multiple languages Biochemistry & Molecular Biology; Chemistry, Multidisciplinary Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/32489