Universität zu Köln

Lefort-Besnard, Jeremy, Vogeley, Kai, Schilbach, Leonhard, Varoquaux, Gael, Thirion, Bertrand, Dumas, Guillaume ORCID: 0000-0002-2253-1844 and Bzdok, Danilo (2020). Patterns of autism symptoms: hidden structure in the ADOS and ADI-R instruments. Transl. Psychiatr., 10 (1). LONDON: NATURE PUBLISHING GROUP. ISSN 2158-3188

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Abstract

We simultaneously revisited the Autism Diagnostic Interview-Revised (ADI-R) and Autism Diagnostic Observation Schedule (ADOS) with a comprehensive data-analytics strategy. Here, the combination of pattern-analysis algorithms and extensive data resources (n=266 patients aged 7-49 years) allowed identifying coherent clinical constellations in and across ADI-R and ADOS assessments widespread in clinical practice. Our clustering approach revealed low- and high-severity patient groups, as well as a group scoring high only in the ADI-R domains, providing quantitative contours for the widely assumed autism subtypes. Sparse regression approaches uncovered the most clinically predictive questionnaire domains. The social and communication domains of the ADI-R showed convincing performance to predict the patients' symptom severity. Finally, we explored the relative importance of each of the ADI-R and ADOS domains conditioning on age, sex, and fluid IQ in our sample. The collective results suggest that (i) identifying autism subtypes and severity for a given individual may be most manifested in the ADI-R social and communication domains, (ii) the ADI-R might be a more appropriate tool to accurately capture symptom severity, and (iii) the ADOS domains were more relevant than the ADI-R domains to capture sex differences.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Lefort-Besnard, Jeremy UNSPECIFIED UNSPECIFIED UNSPECIFIED Vogeley, Kai UNSPECIFIED UNSPECIFIED UNSPECIFIED Schilbach, Leonhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Varoquaux, Gael UNSPECIFIED UNSPECIFIED UNSPECIFIED Thirion, Bertrand UNSPECIFIED UNSPECIFIED UNSPECIFIED Dumas, Guillaume UNSPECIFIED orcid.org/0000-0002-2253-1844 UNSPECIFIED Bzdok, Danilo UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-325467
DOI:	10.1038/s41398-020-00946-8
Journal or Publication Title:	Transl. Psychiatr.
Volume:	10
Number:	1
Date:	2020
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	2158-3188
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SPECTRUM DISORDERS; REPETITIVE BEHAVIORS; DIAGNOSTIC INTERVIEW; DSM-IV; CHILDREN; DEFICITS; DOMAIN; WOMEN Multiple languages Psychiatry Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/32546