Universität zu Köln

Kuemmel, Sherko ORCID: 0000-0001-9355-494X, Harrach, Hakima, Schmutzler, Rita K., Kostara, Athina, Ziegler-Loehr, Katja, Dyson, Mark H., Chiari, Ouafaa and Reinisch, Mattea (2020). Olaparib for metastatic breast cancer in a patient with a germline PALB2 variant. npj Breast Cancer, 6 (1). LONDON: NATURE PUBLISHING GROUP. ISSN 2374-4677

Full text not available from this repository.

Abstract

There is a strong biologic rationale that poly(adenosine diphosphate-ribose) polymerase (PARP) inhibitors may benefit a broader range of metastatic breast cancer (MBC) patients than covered by current approvals, which require a germline BRCA1/2 sequence variant affecting function. We report a patient with germline/somatic BRCA1/2 wild-type MBC, who had a dramatic response to the PARP inhibitor olaparib of at least 8 months' duration. The patient is a 37-year-old woman with recurrent, hormone receptor-positive, HER2-negative MBC that had progressed despite hormonal therapy and palbociclib. Sensitivity to olaparib was likely conferred by a germline sequence variant affecting function in PALB2 (exon 1, c.18G>T, p.(=)). This case documenting activity of olaparib monotherapy in germline/somatic BRCA1/2 wild-type MBC illustrates that the clinical potential of PARP inhibition in MBC extends beyond currently approved indications to additional patients whose tumors have (epi)genetic changes affecting homologous recombination repair.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kuemmel, Sherko UNSPECIFIED orcid.org/0000-0001-9355-494X UNSPECIFIED Harrach, Hakima UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmutzler, Rita K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kostara, Athina UNSPECIFIED UNSPECIFIED UNSPECIFIED Ziegler-Loehr, Katja UNSPECIFIED UNSPECIFIED UNSPECIFIED Dyson, Mark H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Chiari, Ouafaa UNSPECIFIED UNSPECIFIED UNSPECIFIED Reinisch, Mattea UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-325776
DOI:	10.1038/s41523-020-00174-9
Journal or Publication Title:	npj Breast Cancer
Volume:	6
Number:	1
Date:	2020
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	2374-4677
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MUTATION; BRCA2 Multiple languages Oncology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/32577