Universität zu Köln

Davies, Kerrie, Lawrence, Jody, Berry, Claire, Davis, Georgina, Yu, Holly, Cai, Bing, Gonzalez, Elisa, Prantner, Ida, Kurcz, Andrea, Macovei, Ioana, Pituch, Hanna, Novakova, Elena, Nyc, Otakar, Gaertner, Barbara, Berger, Fabian K., Oleastro, Monica, Cornely, Oliver A., Vehreschild, Maria J. G. T., Pedneault, Louise and Wilcox, Mark (2020). Risk Factors for PrimaryClostridium difficileInfection; Results From the Observational Study of Risk Factors forClostridium difficileInfection in Hospitalized Patients With Infective Diarrhea (ORCHID). Front. Public Health, 8. LAUSANNE: FRONTIERS MEDIA SA. ISSN 2296-2565

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Abstract

Background:There are inconsistent data on the risk factors forClostridium difficileinfection (CDI) in the literature. Aims:To use twoC. difficileinfection (CDI) case-control study groups to compare risk factors in hospitalized patients with diarrhea across different countries. Methods:A multi-center group of CDI cases/controls were identified by standardized testing from seven countries from the prior EUropean, multi-center, prospective bi-annual point prevalence study ofCLostridium difficileInfection in hospitalized patients with Diarrhea (EUCLID). A second group of CDI cases/controls was identified from a single center in Germany [parallel study site (PSS)]. Data were extracted from the medical notes to assess CDI risk factors. Univariate analyses and multivariate logistic regression models were used to identify and compare risk factors between the two groups. Results:There were 253 and 158 cases and 921 and 584 controls in the PSS and EUCLID groups, respectively. Significant variables from univariate analyses in both groups were age >= 65, number of antibiotics (OR 1.2 for each additional antibiotic) and prior hospital admission (allp< 0.001). Congestive heart failure, diabetes, admission from assisted living or Emergency Department, proton pump inhibitors, and chronic renal disease were significant in PSS (allp< 0.05) but not EUCLID. Dementia and admitted with other bacterial diseases were significant in EUCLID (p< 0.05) but not PSS. Following multivariate analyses, age >= 65, number of antibiotics and prior hospital admission were consistently identified as CDI risk factors in each individual group and combined datasets. Conclusion:Our results show that the same CDI risk factors were identified across datasets. These were age >= 65 years, antibiotic use and prior hospital admission. Importantly, the odds of developing CDI increases with each extra antibiotic prescribed.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Davies, Kerrie UNSPECIFIED UNSPECIFIED UNSPECIFIED Lawrence, Jody UNSPECIFIED UNSPECIFIED UNSPECIFIED Berry, Claire UNSPECIFIED UNSPECIFIED UNSPECIFIED Davis, Georgina UNSPECIFIED UNSPECIFIED UNSPECIFIED Yu, Holly UNSPECIFIED UNSPECIFIED UNSPECIFIED Cai, Bing UNSPECIFIED UNSPECIFIED UNSPECIFIED Gonzalez, Elisa UNSPECIFIED UNSPECIFIED UNSPECIFIED Prantner, Ida UNSPECIFIED UNSPECIFIED UNSPECIFIED Kurcz, Andrea UNSPECIFIED UNSPECIFIED UNSPECIFIED Macovei, Ioana UNSPECIFIED UNSPECIFIED UNSPECIFIED Pituch, Hanna UNSPECIFIED UNSPECIFIED UNSPECIFIED Novakova, Elena UNSPECIFIED UNSPECIFIED UNSPECIFIED Nyc, Otakar UNSPECIFIED UNSPECIFIED UNSPECIFIED Gaertner, Barbara UNSPECIFIED UNSPECIFIED UNSPECIFIED Berger, Fabian K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Oleastro, Monica UNSPECIFIED UNSPECIFIED UNSPECIFIED Cornely, Oliver A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Vehreschild, Maria J. G. T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pedneault, Louise UNSPECIFIED UNSPECIFIED UNSPECIFIED Wilcox, Mark UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-326166
DOI:	10.3389/fpubh.2020.00293
Journal or Publication Title:	Front. Public Health
Volume:	8
Date:	2020
Publisher:	FRONTIERS MEDIA SA
Place of Publication:	LAUSANNE
ISSN:	2296-2565
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CLOSTRIDIUM-DIFFICILE; COHORT; EPIDEMIOLOGY; MULTICENTER; PREDICTION; VALIDATION; BURDEN Multiple languages Public, Environmental & Occupational Health Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/32616