Universität zu Köln

Hayashi, Takahiko ORCID: 0000-0001-8704-680X, Schrittenlocher, Silvia, Siebelmann, Sebastian, Matthaei, Mario, Franklin, Jeremy, Bachmann, Bjoern and Cursiefen, Claus (2020). Risk factors for endothelial cell loss after Descemet membrane endothelial keratoplasty (DMEK). Sci Rep, 10 (1). LONDON: NATURE PUBLISHING GROUP. ISSN 2045-2322

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Abstract

This study aimed to identify the risk factors for endothelial cell density (ECD) loss after Descemet membrane endothelial keratoplasty (DMEK) and analyse whether donor tissues from cold versus organ culture differ in terms of ECD loss after DMEK. Consecutive DMEK cases from a prospective database for Fuchs' endothelial corneal dystrophy were retrospectively analysed between 2011 and 2016 at the University of Cologne, and the possible risk factors for ECD loss, including patient-related factors, type of tamponade (air or 20% sulphur hexafluoride gas), type of surgery (triple DMEK or DMEK alone), re-bubbling, immune rejection, and donor-related factors were determined. Eight hundred and forty-one eyes were selected. There was no significant difference in the best-corrected visual acuity (logarithm of the minimal angle of resolution) and corneal thickness (P=0.540 and P=0.667) between groups. Immune reactions were more common in cold cultures (P=0.019), but ECD loss (1 year after DMEK) was greater in organ cultures (38.3 +/- 0.8%) than in cold cultures (34.7 +/- 1.4%) (P=0.022). Only re-bubbling was significantly associated with ECD loss (P<0.001). Re-bubbling was found to be a key factor for ECD loss at 1 year after DMEK.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hayashi, Takahiko UNSPECIFIED orcid.org/0000-0001-8704-680X UNSPECIFIED Schrittenlocher, Silvia UNSPECIFIED UNSPECIFIED UNSPECIFIED Siebelmann, Sebastian UNSPECIFIED UNSPECIFIED UNSPECIFIED Matthaei, Mario UNSPECIFIED UNSPECIFIED UNSPECIFIED Franklin, Jeremy UNSPECIFIED UNSPECIFIED UNSPECIFIED Bachmann, Bjoern UNSPECIFIED UNSPECIFIED UNSPECIFIED Cursiefen, Claus UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-326894
DOI:	10.1038/s41598-020-68023-0
Journal or Publication Title:	Sci Rep
Volume:	10
Number:	1
Date:	2020
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	2045-2322
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ALLOGRAFT-REJECTION; AIR; PRESERVATION; 20-PERCENT; DENSITY; CORNEA; TISSUE Multiple languages Multidisciplinary Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/32689