Universität zu Köln

Koch, Maximilian, Reinartz, Sebastian, Saggau, Julia, Knittel, Gero, Rosen, Natascha, Fedorchenko, Oleg, Thelen, Lisa, Barthel, Romy, Reinart, Nina, Seeger-Nukpezah, Tamina, Reinhardt, Hans Christian, Hallek, Michael and Nguyen, Phuong-Hien (2020). Meta-Analysis Reveals Significant Sex Differences in Chronic Lymphocytic Leukemia Progression in theE mu-TCL1Transgenic Mouse Model. Cancers, 12 (7). BASEL: MDPI. ISSN 2072-6694

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Abstract

TheE mu-TCL1transgenic mouse model represents the most widely and extensively used animal model for chronic lymphocytic leukemia (CLL). In this report, we performed a meta-analysis of leukemia progression in over 300 individualE mu-TCL1transgenic mice and discovered a significantly accelerated disease progression in females compared to males. This difference is also reflected in an aggressive CLL mouse model with additional deletion ofTp53besides theTCL1transgene. Moreover, after serial adoptive transplantation of murine CLL cells, female recipients also succumbed to CLL earlier than male recipients. This sex-related disparity in the murine models is markedly contradictory to the human CLL condition. Thus, due to our observation we urge both careful consideration in the experimental design and accurate description of theE mu-TCL1transgenic cohorts in future studies.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Koch, Maximilian UNSPECIFIED UNSPECIFIED UNSPECIFIED Reinartz, Sebastian UNSPECIFIED UNSPECIFIED UNSPECIFIED Saggau, Julia UNSPECIFIED UNSPECIFIED UNSPECIFIED Knittel, Gero UNSPECIFIED UNSPECIFIED UNSPECIFIED Rosen, Natascha UNSPECIFIED UNSPECIFIED UNSPECIFIED Fedorchenko, Oleg UNSPECIFIED UNSPECIFIED UNSPECIFIED Thelen, Lisa UNSPECIFIED UNSPECIFIED UNSPECIFIED Barthel, Romy UNSPECIFIED UNSPECIFIED UNSPECIFIED Reinart, Nina UNSPECIFIED UNSPECIFIED UNSPECIFIED Seeger-Nukpezah, Tamina UNSPECIFIED UNSPECIFIED UNSPECIFIED Reinhardt, Hans Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Hallek, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Nguyen, Phuong-Hien UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-327402
DOI:	10.3390/cancers12071980
Journal or Publication Title:	Cancers
Volume:	12
Number:	7
Date:	2020
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2072-6694
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ESTROGEN-RECEPTOR; TCL1; CELL; CANCER; KINASE Multiple languages Oncology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/32740