Universität zu Köln

Barsch, Friedrich, Niedermair, Tanja, Mamilos, Andreas, Schmitt, Volker H., Grevenstein, David ORCID: 0000-0003-4823-7739, Babel, Maximilian, Burgoyne, Thomas ORCID: 0000-0002-8428-720X, Shoemark, Amelia ORCID: 0000-0001-7360-6060 and Brochhausen, Christoph (2020). Physiological and Pathophysiological Aspects of Primary Cilia-A Literature Review with View on Functional and Structural Relationships in Cartilage. Int. J. Mol. Sci., 21 (14). BASEL: MDPI. ISSN 1422-0067

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Abstract

Cilia are cellular organelles that project from the cell. They occur in nearly all non-hematopoietic tissues and have different functions in different tissues. In mesenchymal tissues primary cilia play a crucial role in the adequate morphogenesis during embryological development. In mature articular cartilage, primary cilia fulfil chemo- and mechanosensitive functions to adapt the cellular mechanisms on extracellular changes and thus, maintain tissue homeostasis and morphometry. Ciliary abnormalities in osteoarthritic cartilage could represent pathophysiological relationships between ciliary dysfunction and tissue deformation. Nevertheless, the molecular and pathophysiological relationships of 'Primary Cilia' (PC) in the context of osteoarthritis is not yet fully understood. The present review focuses on the current knowledge about PC and provide a short but not exhaustive overview of their role in cartilage.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Barsch, Friedrich UNSPECIFIED UNSPECIFIED UNSPECIFIED Niedermair, Tanja UNSPECIFIED UNSPECIFIED UNSPECIFIED Mamilos, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmitt, Volker H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Grevenstein, David UNSPECIFIED orcid.org/0000-0003-4823-7739 UNSPECIFIED Babel, Maximilian UNSPECIFIED UNSPECIFIED UNSPECIFIED Burgoyne, Thomas UNSPECIFIED orcid.org/0000-0002-8428-720X UNSPECIFIED Shoemark, Amelia UNSPECIFIED orcid.org/0000-0001-7360-6060 UNSPECIFIED Brochhausen, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-327545
DOI:	10.3390/ijms21144959
Journal or Publication Title:	Int. J. Mol. Sci.
Volume:	21
Number:	14
Date:	2020
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	1422-0067
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language INTRAFLAGELLAR TRANSPORT PROTEINS; CHONDROCYTE PRIMARY CILIUM; ARTICULAR-CARTILAGE; PLATE CARTILAGE; GROWTH; BONE; CILIOGENESIS; EXPRESSION; PATHWAYS; ROLES Multiple languages Biochemistry & Molecular Biology; Chemistry, Multidisciplinary Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/32754