Universität zu Köln

Hayashi, Takahiko ORCID: 0000-0001-8704-680X, Hos, Deniz, Schrittenlocher, Silvia, Siebelmann, Sebastian, Matthaei, Mario, Franklin, Jeremy, Clahsen, Thomas, Bock, Felix, Bachmann, Bjoern and Cursiefen, Claus (2020). Effect of Iris Color on the Outcome of Descemet Membrane Endothelial Keratoplasty. Cornea, 39 (7). S. 846 - 851. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 1536-4798

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Abstract

Purpose: To explore the impact of iris color on the outcome of Descemet membrane endothelial keratoplasty (DMEK). Methods: Consecutive cases of Fuchs endothelial dystrophy after DMEK were retrospectively analyzed from the prospective Cologne DMEK database between 2011 and 2017 at the University of Cologne, Germany. Iris pictures were graded by color into blue, green, or brown and compared regarding outcome parameters including best-corrected visual acuity (converted to logarithm of the minimal angle of resolution), central corneal thickness, endothelial cell density (ECD), each at preoperative (baseline) and postoperative 12 months, rebubbling rates, cystoid macular edema (CME), and immune rejections after surgery. Results: One thousand one hundred six eyes of 814 patients were included in this study that consisted of 354 blue eyes, 418 green eyes, and 244 brown eyes. There was no significant correlation between iris color and any parameter (best corrected visual acuity;P= 0.064 at preoperatively,P= 0.959 at 12 months) (ECD;P= 0.158 preoperatively,P= 0.859 at 12 months) (central corneal thickness;P= 0.148 preoperatively,P= 0.252 at 12 months). The loss of ECD at 12 months after surgery was 37.2% +/- 1.0% in blue eyes, 37.2% +/- 0.9% in green eyes, and 37.2% +/- 1.2% in brown eyes (P= 0.999). Immune rejections were 1.7%, 2.9%, and 0.8% (P= 0.168) in blue, green, and brown eyes, respectively. Rebubbling rates and CME incidence were similar in each group (P= 0.129, andP= 0.552 respectively). Conclusions: The iris color has no significant impact on the outcome after DMEK. Thus, DMEK can be applied effectively, regardless of the iris color.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hayashi, Takahiko UNSPECIFIED orcid.org/0000-0001-8704-680X UNSPECIFIED Hos, Deniz UNSPECIFIED UNSPECIFIED UNSPECIFIED Schrittenlocher, Silvia UNSPECIFIED UNSPECIFIED UNSPECIFIED Siebelmann, Sebastian UNSPECIFIED UNSPECIFIED UNSPECIFIED Matthaei, Mario UNSPECIFIED UNSPECIFIED UNSPECIFIED Franklin, Jeremy UNSPECIFIED UNSPECIFIED UNSPECIFIED Clahsen, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Bock, Felix UNSPECIFIED UNSPECIFIED UNSPECIFIED Bachmann, Bjoern UNSPECIFIED UNSPECIFIED UNSPECIFIED Cursiefen, Claus UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-327780
DOI:	10.1097/ICO.0000000000002305
Journal or Publication Title:	Cornea
Volume:	39
Number:	7
Page Range:	S. 846 - 851
Date:	2020
Publisher:	LIPPINCOTT WILLIAMS & WILKINS
Place of Publication:	PHILADELPHIA
ISSN:	1536-4798
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MELANOCYTE-STIMULATING HORMONE; GRAFT-SURVIVAL; MACULAR EDEMA; REJECTION; RISK Multiple languages Ophthalmology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/32778