Manchia, Mirko, Vieta, Eduard, Smeland, Olav B., Altimus, Cara, Bechdolf, Andreas, Bellivier, Frank, Bergink, Veerle, Fagiolini, Andrea, Geddes, John R., Hajek, Tomas ORCID: 0000-0003-0281-8458, Henry, Chantal, Kupka, Ralph, Lagerberg, Trine, V, Licht, Rasmus W., Martinez-Cengotitabengoa, Monica, Morken, Gunnar ORCID: 0000-0003-1972-5901, Nielsen, Rene E., Gonzalez Pinto, Ana, Reif, Andreas, Rietschel, Marcella, Ritter, Phillip, Schulze, Thomas G., Scott, Jan, Severus, Emanuel, Yildiz, Aysegul, Kessing, Lars Vedel, Bauer, Michael, Goodwin, Guy M. and Andreassen, Ole A. (2020). Translating big data to better treatment in bipolar disorder - a manifesto for coordinated action. Eur. Neuropsychopharmacol., 36. S. 121 - 137. AMSTERDAM: ELSEVIER. ISSN 1873-7862

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Abstract

Bipolar disorder (BD) is a major healthcare and socio-economic challenge. Despite its substantial burden on society, the research activity in BD is much smaller than its economic impact appears to demand. There is a consensus that the accurate identification of the underlying pathophysiology for BD is fundamental to realize major health benefits through better treatment and preventive regimens. However, to achieve these goals requires coordinated action and innovative approaches to boost the discovery of the neurobiological underpinnings of BD, and rapid translation of research findings into development and testing of better and more specific treatments. To this end, we here propose that only a large-scale coordinated action can be successful in integrating international big-data approaches with real-world clinical interventions. This could be achieved through the creation of a Global Bipolar Disorder Foundation, which could bring government, industry and philanthropy together in common cause. A global initiative for BD research would come at a highly opportune time given the seminal advances promised for our understanding of the genetic and brain basis of the disease and the obvious areas of unmet clinical need. Such an endeavour would embrace the principles of open science and see the strong involvement of user groups and integration of dissemination and public involvement with the research programs. We believe the time is right for a step change in our approach to understanding, treating and even preventing BD effectively. (c) 2020 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license. (http://creativecommons.org/licenses/by/4.0/)

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Manchia, MirkoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vieta, EduardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Smeland, Olav B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Altimus, CaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bechdolf, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bellivier, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bergink, VeerleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fagiolini, AndreaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Geddes, John R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hajek, TomasUNSPECIFIEDorcid.org/0000-0003-0281-8458UNSPECIFIED
Henry, ChantalUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kupka, RalphUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lagerberg, Trine, VUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Licht, Rasmus W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Martinez-Cengotitabengoa, MonicaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Morken, GunnarUNSPECIFIEDorcid.org/0000-0003-1972-5901UNSPECIFIED
Nielsen, Rene E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gonzalez Pinto, AnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reif, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rietschel, MarcellaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ritter, PhillipUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schulze, Thomas G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Scott, JanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Severus, EmanuelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yildiz, AysegulUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kessing, Lars VedelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bauer, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Goodwin, Guy M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Andreassen, Ole A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-328094
DOI: 10.1016/j.euroneuro.2020.05.006
Journal or Publication Title: Eur. Neuropsychopharmacol.
Volume: 36
Page Range: S. 121 - 137
Date: 2020
Publisher: ELSEVIER
Place of Publication: AMSTERDAM
ISSN: 1873-7862
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
GENOME-WIDE ASSOCIATION; PSYCHIATRIC-DISORDERS; SUGGESTIVE LINKAGE; LITHIUM TREATMENT; I DISORDER; ONSET; SCHIZOPHRENIA; PSYCHOSIS; FRAMEWORK; CAREMultiple languages
Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; PsychiatryMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/32809

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