Universität zu Köln

Atta, Ghada, Tempfer, Herbert ORCID: 0000-0003-4043-4033, Kaser-Eichberger, Alexandra, Guo, Yongwei ORCID: 0000-0001-9195-0770, Schroedl, Falk, Traweger, Andreas and Heindl, Ludwig M. (2020). The lymphangiogenic and hemangiogenic privilege of the human sclera. Ann. Anat.-Anat. Anz., 230. MUNICH: ELSEVIER GMBH. ISSN 1618-0402

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Abstract

Purpose: Most organs of the human body are supplied with a dense network of blood and lymphatic vessels. However, some tissues are either hypovascular or completely devoid of vessels for proper function, such as the ocular tissues sclera and cornea, cartilage and tendons. Since many pathological conditions are affecting the human sclera, this review is focussing on the lymphangiogenic and hemangiogenic privilege in the human sclera. Methods: This article gives an overview of the current literature based on a PubMed search as well as observations and experience from clinical practice. Results: The healthy human sclera is the outer covering layer of the eye globe consisting mainly of collagenous extracellular matrix and fibroblasts. Physiologically, the sclera shows only a superficial network of blood vessels and a lack of lymphatic vessels. This vascular privilege is actively regulated by balancing anti- and proangiogenic factors expressed by cells within the sclera. In pathological situations, such as open globe injuries or ciliary body melanomas with extraocular extension, lymphatic vessels can secondarily invade the sclera and the inner eye. This mechanism most likely is important for tumor cell metastasis, wound healing, immunologic defense against intruding microorganism, and autoimmune reactions against intraocular antigens. Conclusions: The human sclera is characterized by a tightly regulated vascular network that can be compromised in pathological situations, such as injuries or intraocular tumors affecting healing outcomes Therefore, the molecular and cellular mechanisms underlying wound healing following surgical interventions deserve further attention, in order to devise more effective therapeutic strategies. (C) 2020 Elsevier GmbH. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Atta, Ghada UNSPECIFIED UNSPECIFIED UNSPECIFIED Tempfer, Herbert UNSPECIFIED orcid.org/0000-0003-4043-4033 UNSPECIFIED Kaser-Eichberger, Alexandra UNSPECIFIED UNSPECIFIED UNSPECIFIED Guo, Yongwei UNSPECIFIED orcid.org/0000-0001-9195-0770 UNSPECIFIED Schroedl, Falk UNSPECIFIED UNSPECIFIED UNSPECIFIED Traweger, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Heindl, Ludwig M. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-328533
DOI:	10.1016/j.aanat.2020.151485
Journal or Publication Title:	Ann. Anat.-Anat. Anz.
Volume:	230
Date:	2020
Publisher:	ELSEVIER GMBH
Place of Publication:	MUNICH
ISSN:	1618-0402
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ENDOTHELIAL GROWTH-FACTOR; LYMPHATIC VESSELS; FACTOR-C; INFLAMMATORY LYMPHANGIOGENESIS; SULFATED PROTEOGLYCANS; TRABECULAR MESHWORK; CILIARY-BODY; COLLAGEN; ANGIOGENESIS; CORNEAL Multiple languages Anatomy & Morphology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/32853