Verweij, Paul E., Rijnders, Bart J. A., Bruggemann, Roger J. M., Azoulay, Elie ORCID: 0000-0002-8162-1508, Bassetti, Matteo, Blot, Stijn ORCID: 0000-0003-2145-0345, Calandra, Thierry ORCID: 0000-0003-3051-1285, Clancy, Cornelius J., Cornely, Oliver A., Chiller, Tom, Depuydt, Pieter, Giacobbe, Daniele Roberto ORCID: 0000-0003-2385-1759, Janssen, Nico A. F., Kullberg, Bart-Jan, Lagrou, Katrien, Lass-Florl, Cornelia, Lewis, Russell E., Liu, Peter Wei-Lun, Lortholary, Olivier, Maertens, Johan, Martin-Loeches, Ignacio, Nguyen, M. Hong, Patterson, Thomas F., Rogers, Thomas R., Schouten, Jeroen A., Spriet, Isabel, Vanderbeke, Lore, Wauters, Joost and van de Veerdonk, Frank L. (2020). Review of influenza-associated pulmonary aspergillosis in ICU patients and proposal for a case definition: an expert opinion. Intensive Care Med., 46 (8). S. 1524 - 1536. NEW YORK: SPRINGER. ISSN 1432-1238

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Abstract

Purpose Invasive pulmonary aspergillosis is increasingly reported in patients with influenza admitted to the intensive care unit (ICU). Classification of patients with influenza-associated pulmonary aspergillosis (IAPA) using the current definitions for invasive fungal diseases has proven difficult, and our aim was to develop case definitions for IAPA that can facilitate clinical studies. Methods A group of 29 international experts reviewed current insights into the epidemiology, diagnosis and management of IAPA and proposed a case definition of IAPA through a process of informal consensus. Results Since IAPA may develop in a wide range of hosts, an entry criterion was proposed and not host factors. The entry criterion was defined as a patient requiring ICU admission for respiratory distress with a positive influenza test temporally related to ICU admission. In addition, proven IAPA required histological evidence of invasive septate hyphae and mycological evidence forAspergillus. Probable IAPA required the detection of galactomannan or positiveAspergillusculture in bronchoalveolar lavage (BAL) or serum with pulmonary infiltrates or a positive culture in upper respiratory samples with bronchoscopic evidence for tracheobronchitis or cavitating pulmonary infiltrates of recent onset. The IAPA case definitions may be useful to classify patients with COVID-19-associated pulmonary aspergillosis (CAPA), while awaiting further studies that provide more insight into the interaction betweenAspergillusand the SARS-CoV-2-infected lung. Conclusion A consensus case definition of IAPA is proposed, which will facilitate research into the epidemiology, diagnosis and management of this emerging acute and severeAspergillusdisease, and may be of use to study CAPA.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Verweij, Paul E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rijnders, Bart J. A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bruggemann, Roger J. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Azoulay, ElieUNSPECIFIEDorcid.org/0000-0002-8162-1508UNSPECIFIED
Bassetti, MatteoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Blot, StijnUNSPECIFIEDorcid.org/0000-0003-2145-0345UNSPECIFIED
Calandra, ThierryUNSPECIFIEDorcid.org/0000-0003-3051-1285UNSPECIFIED
Clancy, Cornelius J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cornely, Oliver A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chiller, TomUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Depuydt, PieterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Giacobbe, Daniele RobertoUNSPECIFIEDorcid.org/0000-0003-2385-1759UNSPECIFIED
Janssen, Nico A. F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kullberg, Bart-JanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lagrou, KatrienUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lass-Florl, CorneliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lewis, Russell E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Liu, Peter Wei-LunUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lortholary, OlivierUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maertens, JohanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Martin-Loeches, IgnacioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nguyen, M. HongUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Patterson, Thomas F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rogers, Thomas R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schouten, Jeroen A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Spriet, IsabelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vanderbeke, LoreUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wauters, JoostUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van de Veerdonk, Frank L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-329368
DOI: 10.1007/s00134-020-06091-6
Journal or Publication Title: Intensive Care Med.
Volume: 46
Number: 8
Page Range: S. 1524 - 1536
Date: 2020
Publisher: SPRINGER
Place of Publication: NEW YORK
ISSN: 1432-1238
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
INFECTIOUS-DISEASES SOCIETY; CRITICALLY-ILL PATIENTS; PRACTICE GUIDELINES; FUNGAL-INFECTIONS; VORICONAZOLE; MANAGEMENT; DIAGNOSIS; EFFICACY; SAFETY; VIRUSMultiple languages
Critical Care MedicineMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/32936

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