Universität zu Köln

Kew, Chun, Huang, Wenming, Fischer, Julia, Ganesan, Raja, Robinson, Nirmal ORCID: 0000-0002-7361-9491 and Antebi, Adam (2020). Evolutionarily conserved regulation of immunity by the splicing actor RNP-6/PUF60. eLife, 9. CAMBRIDGE: ELIFE SCIENCES PUBLICATIONS LTD. ISSN 2050-084X

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Abstract

Splicing is a vital cellular process that modulates important aspects of animal physiology, yet roles in regulating innate immunity are relatively unexplored. From genetic screens in C. elegans, we identified splicing factor RNP-6/PUF60 whose activity suppresses immunity, but promotes longevity, suggesting a tradeoff between these processes. Bacterial pathogen exposure affects gene expression and splicing in a rnp-6 dependent manner, and rnp-6 gain and loss-of-function activities reveal an active role in immune regulation. Another longevity promoting splicing factor, SFA-1, similarly exerts an immuno-suppressive effect, working downstream or parallel to RNP-6. RNP-6 acts through TIR-1/PMK-1/MAPK signaling to modulate immunity. The mammalian homolog, PUF60, also displays anti-inflammatory properties, and its levels swiftly decrease after bacterial infection in mammalian cells, implying a role in the host response. Altogether our findings demonstrate an evolutionarily conserved modulation of immunity by specific components of the splicing machinery.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kew, Chun UNSPECIFIED UNSPECIFIED UNSPECIFIED Huang, Wenming UNSPECIFIED UNSPECIFIED UNSPECIFIED Fischer, Julia UNSPECIFIED UNSPECIFIED UNSPECIFIED Ganesan, Raja UNSPECIFIED UNSPECIFIED UNSPECIFIED Robinson, Nirmal UNSPECIFIED orcid.org/0000-0002-7361-9491 UNSPECIFIED Antebi, Adam UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-329910
DOI:	10.7554/eLife.57591
Journal or Publication Title:	eLife
Volume:	9
Date:	2020
Publisher:	ELIFE SCIENCES PUBLICATIONS LTD
Place of Publication:	CAMBRIDGE
ISSN:	2050-084X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CAENORHABDITIS-ELEGANS; INNATE IMMUNITY; EXPRESSION; TRANSCRIPTION; LONGEVITY; PATHOGEN; PATHWAY; GENES; PUF60; ACTIVATION Multiple languages Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/32991