Universität zu Köln

Muke, Ines, Sprenger, Alina, Bobylev, Ilja, Wiemer, Valerie, Barham, Mohammed, Neiss, Wolfram Friedrich and Lehmann, Helmar Christoph (2020). Ultrastructural characterization of mitochondrial damage in experimental autoimmune neuritis. J. Neuroimmunol., 343. AMSTERDAM: ELSEVIER. ISSN 1872-8421

Full text not available from this repository.

Abstract

Data are sparse about mitochondrial damage in GBS and in its most frequently employed animal model, experimental autoimmune neuritis (FAN). We here characterized changes in mitochondrial content and morphology at different time points during EAN by use of ultrastructural imaging and immunofluorescent labelling. Histological examination revealed that demyelinated axons and their adjacent Schwann cells showed reduced mitochondrial content and remaining mitochondria appeared swollen with greater diameter in Schwann cells and unmyelinated axons. Our findings indicate that in FAN, particularly mitochondria in Schwann cells are damaged. Further studies are warranted to address whether these changes are amenable to novel, mitoprotective treatments.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Muke, Ines UNSPECIFIED UNSPECIFIED UNSPECIFIED Sprenger, Alina UNSPECIFIED UNSPECIFIED UNSPECIFIED Bobylev, Ilja UNSPECIFIED UNSPECIFIED UNSPECIFIED Wiemer, Valerie UNSPECIFIED UNSPECIFIED UNSPECIFIED Barham, Mohammed UNSPECIFIED UNSPECIFIED UNSPECIFIED Neiss, Wolfram Friedrich UNSPECIFIED UNSPECIFIED UNSPECIFIED Lehmann, Helmar Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-329988
DOI:	10.1016/j.jneuroim.2020.577218
Journal or Publication Title:	J. Neuroimmunol.
Volume:	343
Date:	2020
Publisher:	ELSEVIER
Place of Publication:	AMSTERDAM
ISSN:	1872-8421
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language EXPERIMENTAL ALLERGIC NEURITIS; PAINFUL PERIPHERAL NEUROPATHY; CELL RESPONSES; LEWIS RAT; MODEL; DEMYELINATION; MYELIN; INFLAMMATION; PREVENTION; APOPTOSIS Multiple languages Immunology; Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/32998