Universität zu Köln

Jordan, J., Hellweg, C. E., Mulder, E. and Stern, C. (2020). From human terrestrial models to new preventive measures for ocular changes in astronauts Results of the German Aerospace Center studies. Ophthalmologe, 117 (8). S. 740 - 746. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1433-0423

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Abstract

Background Ocular changes in astronauts, particularly the spaceflight associated neuro-ocular syndrome (SANS), pose a medical challenge for which no suitable preventive measures exist. During long-duration spaceflight missions, e.g. to the Moon and Mars, SANS and radiation-induced cataract could affect the health and performance of crews and jeopardize the success of missions. Mechanistic studies and development of preventive measures require suitable terrestrial models. Objective Overview on the most recent research and future plans in space medicine. Material and methods Search for relevant publications using PubMed. Results Bed rest studies at the German Aerospace Center (DLR) demonstrated that strict bed rest in a -6 degrees head down tilt position reproduces changes just like SANS on Earth. This model including creation of optic disc edema is applied in human studies testing influences of artificial gravity through short arm centrifugation as a preventive method. The unique research facility :envihab provides the opportunity to also simulate the ambient conditions of the International Space Station during bed rest studies. Conclusion Future head down tilt bed rest studies will serve to systematically test preventive measures for SANS. Similar investigations would be difficult to realize under real space conditions. Through close collaboration between space medicine and terrestrial ophthalmology, this research can benefit patients on Earth.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Jordan, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hellweg, C. E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mulder, E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Stern, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-330310
DOI:	10.1007/s00347-020-01133-2
Journal or Publication Title:	Ophthalmologe
Volume:	117
Number:	8
Page Range:	S. 740 - 746
Date:	2020
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1433-0423
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HEAD-DOWN TILT; CARBON-DIOXIDE; PRESSURE; RADIATION Multiple languages Ophthalmology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/33031