Universität zu Köln

Stoessel, Sandra, Neu, Marie A. ORCID: 0000-0002-8564-7115, Wingerter, Arthur, Bloch, Wilhelm, Zimmer, Philipp, Paret, Claudia ORCID: 0000-0002-9094-1634, El Malki, Khalifa, Baumann, Freerk T., Russo, Alexandra, Henninger, Nicole, Lehmann, Nadine, Otto, Henrike and Faber, Joerg (2020). Benefits of Exercise Training for Children and Adolescents Undergoing Cancer Treatment: Results From the Randomized Controlled MUCKI Trial. Front. Pediatr., 8. LAUSANNE: FRONTIERS MEDIA SA. ISSN 2296-2360

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Abstract

Objective:In cancer patients, the impairment in muscle function is a frequently observed phenomenon. However, comprehensive evaluation of the effect of exercise training on muscle function in childhood cancer patients (CCPs) is sparse and therefore investigated in the MUCKI trial. Study Design:In the randomized controlled MUCKI trial, CCPs during intensive cancer treatment and aged 4-18 years were recruited. Eligible patients were enrolled soon after diagnosis as long as they were physically and mentally able to participate in exercise testing and training. Patients of the exercise group (n= 16) participated in average 2.7 +/- 1.2 times per week in a combined resistance and endurance training with moderate exercise intensity, for a time period of 8.0 +/- 2.1 weeks, while patients of the control group (n= 17) received usual care. Leg strength was evaluated as the primary endpoint. Secondary endpoints were 6-min walk performance, arm strength, body composition, fatigue, and health-related quality of life. Results:Comparisons of pre- and post-intervention results were evaluated by baseline and stratification criteria adjusted analysis and showed positive effects for the exercise group regarding leg strength [F-(1,F- 20)= 5.733;p= 0.027*;eta p2= 0.223], walking performance [F-(1,F- 25)= 4.270;p= 0.049*;eta p2= 0.146], fatigue [F-(1,F- 13)= 8.353;p= 0.013*;eta p2= 0.391], self-esteem [F-(1,F- 6)= 6.823;p= 0.040*;eta p2= 0.532], and self-reported strength and endurance capacity [F-(1,F- 6)= 6.273;p= 0.046*;eta p2= 0.511]. No significant differences were found for the other parameters. Conclusion:Within one of the first randomized controlled trials, the present study provides evidence for a positive effect of combined training in CCPs during intensive cancer treatment. Further research is needed to confirm these results and to evaluate their clinical impact.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Stoessel, Sandra UNSPECIFIED UNSPECIFIED UNSPECIFIED Neu, Marie A. UNSPECIFIED orcid.org/0000-0002-8564-7115 UNSPECIFIED Wingerter, Arthur UNSPECIFIED UNSPECIFIED UNSPECIFIED Bloch, Wilhelm UNSPECIFIED UNSPECIFIED UNSPECIFIED Zimmer, Philipp UNSPECIFIED UNSPECIFIED UNSPECIFIED Paret, Claudia UNSPECIFIED orcid.org/0000-0002-9094-1634 UNSPECIFIED El Malki, Khalifa UNSPECIFIED UNSPECIFIED UNSPECIFIED Baumann, Freerk T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Russo, Alexandra UNSPECIFIED UNSPECIFIED UNSPECIFIED Henninger, Nicole UNSPECIFIED UNSPECIFIED UNSPECIFIED Lehmann, Nadine UNSPECIFIED UNSPECIFIED UNSPECIFIED Otto, Henrike UNSPECIFIED UNSPECIFIED UNSPECIFIED Faber, Joerg UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-330538
DOI:	10.3389/fped.2020.00243
Journal or Publication Title:	Front. Pediatr.
Volume:	8
Date:	2020
Publisher:	FRONTIERS MEDIA SA
Place of Publication:	LAUSANNE
ISSN:	2296-2360
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language 6-MINUTE WALK TEST; PHYSICAL-ACTIVITY; PHASE-ANGLE; STRENGTH DEFICITS; HEALTHY-CHILDREN; BODY-COMPOSITION; RELIABILITY; SURVIVORS; FITNESS; GUIDELINES Multiple languages Pediatrics Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/33053