Universität zu Köln

Scaplen, Kristin M., Talay, Mustafa, Nunez, Kavin M., Salamon, Sarah, Waterman, Amanda G., Gang, Sydney, Song, Sophia L., Barnea, Gilad and Kaun, Karla R. (2020). Circuits that encode and guide alcohol-associated preference. eLife, 9. CAMBRIDGE: ELIFE SCIENCES PUBLICATIONS LTD. ISSN 2050-084X

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Abstract

A powerful feature of adaptive memory is its inherent flexibility. Alcohol and other addictive substances can remold neural circuits important for memory to reduce this flexibility. However, the mechanism through which pertinent circuits are selected and shaped remains unclear. We show that circuits required for alcohol-associated preference shift from population level dopaminergic activation to select dopamine neurons that predict behavioral choice in Drosophila melanogaster. During memory expression, subsets of dopamine neurons directly and indirectly modulate the activity of interconnected glutamatergic and cholinergic mushroom body output neurons (MBON). Transsynaptic tracing of neurons important for memory expression revealed a convergent center of memory consolidation within the mushroom body (MB) implicated in arousal, and a structure outside the MB implicated in integration of naive and learned responses. These findings provide a circuit framework through which dopamine neuronal activation shifts from reward delivery to cue onset, and provide insight into the maladaptive nature of memory.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Scaplen, Kristin M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Talay, Mustafa UNSPECIFIED UNSPECIFIED UNSPECIFIED Nunez, Kavin M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Salamon, Sarah UNSPECIFIED UNSPECIFIED UNSPECIFIED Waterman, Amanda G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gang, Sydney UNSPECIFIED UNSPECIFIED UNSPECIFIED Song, Sophia L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Barnea, Gilad UNSPECIFIED UNSPECIFIED UNSPECIFIED Kaun, Karla R. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-330587
DOI:	10.7554/eLife.48730
Journal or Publication Title:	eLife
Volume:	9
Date:	2020
Publisher:	ELIFE SCIENCES PUBLICATIONS LTD
Place of Publication:	CAMBRIDGE
ISSN:	2050-084X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LONG-TERM-MEMORY; DOPAMINERGIC-NEURONS; CENTRAL COMPLEX; BODY NEURONS; ODOR MEMORY; DROSOPHILA; REWARD; BRAIN; ADDICTION; TASTE Multiple languages Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/33058