Universität zu Köln

Sarikcioglu, Levent, Hizay, Arzu, Ozsoy, Umut, Kandemir, Yasemin Behram, Sekerci, Rahime and Angelov, Doychin N. (2020). Assessment of axonal sprouting and motor performance after hypoglossal-facial end-to-side nerve repair: experimental study in rats. Exp. Brain Res., 238 (6). S. 1563 - 1577. NEW YORK: SPRINGER. ISSN 1432-1106

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Abstract

Hypoglossal-facial nerve anastomosis (HFA) aims to reanimate denervated mimic muscles with hypoglossal axons when the transected facial nerve is not accessible. The aim of this study was to evaluate the recovery of HFA using a Y tube in two variants: (1) the proximal stump of the hypoglossal nerve was entubulated to the Y tube (classic Y tube HFA) and (2) the Y tube was sutured to an epineurial window of a slightly damaged hypoglossal nerve (end-to-side Y tube HFA). A total of 48 adult female rats were divided into four groups: intact controls (group 1), sham operated (group 2), classic Y tube HFA (group 3) and end-to-side Y tube HFA (group 4). The abdominal aorta with both common iliac arteries of isogeneic male rats served as the Y-tube conduit. Animals from group 4 recovered better than those from group 3: the degree of collateral axonal branching (3 +/- 1%) was significantly lower than that determined in group 3 (13 +/- 1%). The mean deviation of the tongue from the midline was significantly smaller in group 4 (6 +/- 4 degrees) than that measured in animals from group 3 (41 +/- 6 degrees). In the determination of vibrissal motor function in group 3 and group 4, a decrease in amplitude was found to be - 66% and - 92%, respectively. No differences in the reinnervation pattern of the target muscles were detected. As a result, these surgical models were not determined to be able to improve vibrissal movements. It was concluded that performance of end-to-side Y tube HFA diminishes collateral axonal branching at the lesion site, which in turn, promotes better recovery of tongue- and vibrissal-motor performance.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Sarikcioglu, Levent UNSPECIFIED UNSPECIFIED UNSPECIFIED Hizay, Arzu UNSPECIFIED UNSPECIFIED UNSPECIFIED Ozsoy, Umut UNSPECIFIED UNSPECIFIED UNSPECIFIED Kandemir, Yasemin Behram UNSPECIFIED UNSPECIFIED UNSPECIFIED Sekerci, Rahime UNSPECIFIED UNSPECIFIED UNSPECIFIED Angelov, Doychin N. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-330778
DOI:	10.1007/s00221-020-05835-6
Journal or Publication Title:	Exp. Brain Res.
Volume:	238
Number:	6
Page Range:	S. 1563 - 1577
Date:	2020
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1432-1106
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LONG-TERM EVALUATION; Y-TUBE CONDUIT; PERIPHERAL-NERVE; MANUAL STIMULATION; TERMINOLATERAL NEURORRHAPHY; MORPHOMETRIC EVALUATION; NEURON REGENERATION; SCHWANN-CELLS; SCIATIC-NERVE; GROWTH-FACTOR Multiple languages Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/33077