Universität zu Köln

Schwartz, Stefan ORCID: 0000-0001-8833-5793, Cornely, Oliver A., Hamed, Kamal ORCID: 0000-0003-1896-9736, Marty, Francisco M. ORCID: 0000-0002-3708-8734, Maertens, Johan, Rahav, Galia, Herbrecht, Raoul and Heinz, Werner J. (2020). Isavuconazole for the treatment of patients with invasive fungal diseases involving the central nervous system. Med. Mycol., 58 (4). S. 417 - 425. OXFORD: OXFORD UNIV PRESS. ISSN 1460-2709

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Abstract

The incidence of invasive fungal diseases (IFDs) with central nervous system (CNS) involvement is increasing due to the rising numbers of immunocompromised individuals, such as patients receiving chemotherapy, transplantation procedures, or immune-modulating therapies. CNS IFDs cause significant morbidity and mortality, and treatments are complicated by difficulties in identifying fungal pathogens and delivering antifungal agents to the CNS. Isavuconazole is a novel triazole with broad-spectrum activity that has shown good blood-brain barrier penetration in animal models. We present a retrospective analysis of isavuconazole in the treatment of patients with CNS IFDs and who either participated in the phase III VITAL or SECURE clinical trials, or were included in a named-patient program. A total of 36 patients were identified, including 27 patients from the clinical trials. Of these patients, 47.2% had hematologic malignancies, while 13.9% had no identifiable underlying conditions. Mucorales, Aspergillus species, and Cryptococcus species accounted for 30.6%, 22.2%, and 13.9% of infections, respectively. The overall survival rate was 80.6% at day 42 and 69.4% at day 84, and at the end of treatment, a complete or partial clinical response was achieved in 58.3% of patients. Isavuconazole exhibited clinical activity in a variety of CNS IFDs.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schwartz, Stefan UNSPECIFIED orcid.org/0000-0001-8833-5793 UNSPECIFIED Cornely, Oliver A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hamed, Kamal UNSPECIFIED orcid.org/0000-0003-1896-9736 UNSPECIFIED Marty, Francisco M. UNSPECIFIED orcid.org/0000-0002-3708-8734 UNSPECIFIED Maertens, Johan UNSPECIFIED UNSPECIFIED UNSPECIFIED Rahav, Galia UNSPECIFIED UNSPECIFIED UNSPECIFIED Herbrecht, Raoul UNSPECIFIED UNSPECIFIED UNSPECIFIED Heinz, Werner J. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-330901
DOI:	10.1093/mmy/myz103
Journal or Publication Title:	Med. Mycol.
Volume:	58
Number:	4
Page Range:	S. 417 - 425
Date:	2020
Publisher:	OXFORD UNIV PRESS
Place of Publication:	OXFORD
ISSN:	1460-2709
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CRYPTOCOCCAL MENINGITIS; INFECTIONS; POSACONAZOLE; VORICONAZOLE; MUCORMYCOSIS; PENETRATION; DIAGNOSIS; IBRUTINIB; EFFICACY; THERAPY Multiple languages Infectious Diseases; Mycology; Veterinary Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/33090