Universität zu Köln

Schlautmann, Lena P. and Gehring, Niels H. ORCID: 0000-0001-7792-1164 (2020). A Day in the Life of the Exon Junction Complex. Biomolecules, 10 (6). BASEL: MDPI. ISSN 2218-273X

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Abstract

The exon junction complex (EJC) is an abundant messenger ribonucleoprotein (mRNP) component that is assembled during splicing and binds to mRNAs upstream of exon-exon junctions. EJCs accompany the mRNA during its entire life in the nucleus and the cytoplasm and communicate the information about the splicing process and the position of introns. Specifically, the EJC's core components and its associated proteins regulate different steps of gene expression, including pre-mRNA splicing, mRNA export, translation, and nonsense-mediated mRNA decay (NMD). This review summarizes the most important functions and main protagonists in the life of the EJC. It also provides an overview of the latest findings on the assembly, composition and molecular activities of the EJC and presents them in the chronological order, in which they play a role in the EJC's life cycle.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schlautmann, Lena P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gehring, Niels H. UNSPECIFIED orcid.org/0000-0001-7792-1164 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-331239
DOI:	10.3390/biom10060866
Journal or Publication Title:	Biomolecules
Volume:	10
Number:	6
Date:	2020
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2218-273X
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Biology > Institute for Genetics
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NONSENSE-MEDIATED DECAY; MESSENGER-RNA DECAY; CRYO-EM STRUCTURE; CRYSTAL-STRUCTURE; CORE COMPLEX; BINDING PROTEIN; GENE-EXPRESSION; NUCLEAR IMPORT; EJC-BINDING; TRANSLATION Multiple languages Biochemistry & Molecular Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/33123