Universität zu Köln

Quhal, Fahad ORCID: 0000-0002-8163-6953, Abufaraj, Mohammad ORCID: 0000-0002-6603-6319, Janisch, Florian, Mori, Keiichiro, Lysenko, Ivan, Mostafaei, Hadi, D'Andrea, David, Mathieu, Romain, Enikeev, Dmitry, V, Fajkovic, Harun, Heidenreich, Axel and Shariat, Shahrokh F. (2020). The significance of De Ritis ratio in patients with radiation-recurrent prostate cancer undergoing salvage radical prostatectomy. Arab J. Urol., 18 (4). S. 213 - 219. ABINGDON: TAYLOR & FRANCIS LTD. ISSN 2090-5998

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Abstract

Objective To evaluate the clinical prognostic value of preoperative serum De Ritis ratio (DRR; aspartate aminotransferase/alanine aminotransferase) on postoperative survival outcomes in patients with radiation-recurrent prostate cancer (PCa) who underwent salvage radical prostatectomy (SRP). Patients and methods A retrospective review was conducted of patients with radiation-recurrent PCa who underwent SRP in five tertiary referral centres from 2007 to 2015. An increased preoperative serum DRR was defined as >= 1.35. The association between DRR and postoperative outcomes was tested. Multivariate Cox analyses were performed to identify the independent predictors of biochemical recurrence (BCR), metastases-free survival (MFS), overall survival (OS), and cancer-specific survival (CSS). Results Overall 214 patients underwent SRP, of them 98 (45.8%) with a high serum DRR were included in the study. In a multivariate analysis high DRR was an independent predictor of BCR [hazard ratio (HR) 1.79, 95% confidence interval (CI) 1.16-2.78;P= 0.009]. No significant association was found between preoperative DRR and MFS (HR 1.32, 95% CI 0.53-3.30;P= 0.55), OS (HR 2.35, 95% CI 0.84-6.57;P= 0.10), and CSS (HR 3.36, 95% CI 0.65-17.35;P= 0.15). Conclusion Increased preoperative serum DRR is associated with the development of BCR in patients with radiation-recurrent PCa who underwent SRP. DRR might serve as an early indicator of BCR, which may facilitate recognition of potential relapse and could translate into more intense follow-up and even salvage therapy in selected patients.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Quhal, Fahad UNSPECIFIED orcid.org/0000-0002-8163-6953 UNSPECIFIED Abufaraj, Mohammad UNSPECIFIED orcid.org/0000-0002-6603-6319 UNSPECIFIED Janisch, Florian UNSPECIFIED UNSPECIFIED UNSPECIFIED Mori, Keiichiro UNSPECIFIED UNSPECIFIED UNSPECIFIED Lysenko, Ivan UNSPECIFIED UNSPECIFIED UNSPECIFIED Mostafaei, Hadi UNSPECIFIED UNSPECIFIED UNSPECIFIED D'Andrea, David UNSPECIFIED UNSPECIFIED UNSPECIFIED Mathieu, Romain UNSPECIFIED UNSPECIFIED UNSPECIFIED Enikeev, Dmitry, V UNSPECIFIED UNSPECIFIED UNSPECIFIED Fajkovic, Harun UNSPECIFIED UNSPECIFIED UNSPECIFIED Heidenreich, Axel UNSPECIFIED UNSPECIFIED UNSPECIFIED Shariat, Shahrokh F. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-331383
DOI:	10.1080/2090598X.2020.1771947
Journal or Publication Title:	Arab J. Urol.
Volume:	18
Number:	4
Page Range:	S. 213 - 219
Date:	2020
Publisher:	TAYLOR & FRANCIS LTD
Place of Publication:	ABINGDON
ISSN:	2090-5998
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language Urology & Nephrology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/33138