Universität zu Köln

Kakkassery, Vinodh, Juenemann, Anselm M., Bechrakis, Nikolaos E., Grisanti, Salvatore, Ranjbar, Hdy, Zschoche, Marco and Heindl, Ludwig M. (2020). Ocular lymphoma Precise diagnostics and classification as key for successful personalized treatment. Ophthalmologe, 117 (6). S. 499 - 508. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1433-0423

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Abstract

Background Personalized medicine is nowadays the standard of care for patients with oncological diseases. A prime example is the lymphoma, which has substantial points of contact with ophthalmological care due to the intraocular and periocular involvement. Objective This article provides a description of the current personalized diagnostics and treatment of ocular lymphomas. Methods This article constructs a relationship between the current knowledge in the literature, guidelines and recommendations and the clinical experience with ocular lymphomas. It explains in particular the molecular and also individual personalized treatment concepts. Results The primary suspicion of lymphatic or other ocular oncological diseases is raised by an ophthalmologist based on clinical symptoms. The exact diagnostic procedure is carried out with molecular biological techniques, such as immunohistology and polymerase chain reaction analyses. A staging of the mass is indispensable and the stage classification according to the Ann Arbor criteria for a correct assignment of the lymphoma is of clinical importance. Based on these precise diagnostics an individualized choice of treatment and subsequent personalized follow-up care are carried out. During the complete process from the diagnostic procedure to treatment and aftercare, psycho-oncological support should be offered to the patient. Conclusion Personalized medicine is already actively performed in the care of ocular lymphomas. The patient is in the forefront and plays a decisive role. By considering the special features of the tumor and patient parameters, the life expectation and relapse-free interval as well as quality of life have been improved for many types of lymphoma. It must be assumed that these advantages also apply to ophthalmology.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kakkassery, Vinodh UNSPECIFIED UNSPECIFIED UNSPECIFIED Juenemann, Anselm M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bechrakis, Nikolaos E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Grisanti, Salvatore UNSPECIFIED UNSPECIFIED UNSPECIFIED Ranjbar, Hdy UNSPECIFIED UNSPECIFIED UNSPECIFIED Zschoche, Marco UNSPECIFIED UNSPECIFIED UNSPECIFIED Heindl, Ludwig M. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-331743
DOI:	10.1007/s00347-019-01020-5
Journal or Publication Title:	Ophthalmologe
Volume:	117
Number:	6
Page Range:	S. 499 - 508
Date:	2020
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1433-0423
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language AMERICAN JOINT COMMITTEE; OPHTHALMIC MANIFESTATIONS; INTRAOCULAR LYMPHOMA; ADNEXAL LYMPHOMA; STAGING SYSTEM; VALUABLE TOOL; 7TH EDITION; BIOMARKERS Multiple languages Ophthalmology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/33174