Universität zu Köln

Schiltz, Daniel ORCID: 0000-0003-1096-9336, Tschernitz, Sebastian, Ortner, Christine, Anker, Alexandra, Klein, Silvan, Felthaus, Oliver, Biermann, Niklas, Schreml, Julia, Prantl, Lukas and Schreml, Stephan (2020). Adipose Tissue in Multiple Symmetric Lipomatosis Shows Features of Brown/Beige Fat. Aesthet. Plast. Surg., 44 (3). S. 855 - 862. NEW YORK: SPRINGER. ISSN 1432-5241

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Abstract

Introduction Multiple symmetric lipomatosis (MSL) (syn.: Launois-Bensaude Syndrome, benign symmetric lipomatosis) is a rare disease of fatty tissue. The pathophysiology of MSL still remains unclear, although several approaches have been described in order to understand it. Beside morphological characteristics and some molecular cell biological approaches, little is known about the histological and immunohistochemical characterization of adipose tissue from patients with MSL. Methods From the 45 patients with MSL in our database, 10 were included in the study. Fat tissue samples were collected from affected and unaffected areas. The forearm served as a control area as this area is not affected in MSL. The specimens were analyzed after selected stainings were taken (hematoxylin-eosin = HE, Elastica van Gieson, Ladewig, CD200, CIDEA, myf5, p107, Prdm16, Sca-1, syndecan, UCP1, MAC387, Glut4). Results In patients suffering from MSL, no macroscopic or microscopic morphological difference could be found between affected and unaffected adipose tissue in HE stainings. The majority of samples showed positivity for UCP1 (9/10 clinically affected tissues, 7/10 clinically unaffected tissues) and CD200. Conclusion Marker profiles support the hypothesis that affected adipose tissue derives from brown or beige adipose tissue rather than from white fat.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schiltz, Daniel UNSPECIFIED orcid.org/0000-0003-1096-9336 UNSPECIFIED Tschernitz, Sebastian UNSPECIFIED UNSPECIFIED UNSPECIFIED Ortner, Christine UNSPECIFIED UNSPECIFIED UNSPECIFIED Anker, Alexandra UNSPECIFIED UNSPECIFIED UNSPECIFIED Klein, Silvan UNSPECIFIED UNSPECIFIED UNSPECIFIED Felthaus, Oliver UNSPECIFIED UNSPECIFIED UNSPECIFIED Biermann, Niklas UNSPECIFIED UNSPECIFIED UNSPECIFIED Schreml, Julia UNSPECIFIED UNSPECIFIED UNSPECIFIED Prantl, Lukas UNSPECIFIED UNSPECIFIED UNSPECIFIED Schreml, Stephan UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-331825
DOI:	10.1007/s00266-020-01666-6
Journal or Publication Title:	Aesthet. Plast. Surg.
Volume:	44
Number:	3
Page Range:	S. 855 - 862
Date:	2020
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1432-5241
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language UNCOUPLING PROTEIN; LAUNOIS-BENSAUDE; BROWN ADIPOCYTE Multiple languages Surgery Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/33182