Universität zu Köln

Enders, Philip ORCID: 0000-0002-9527-4957, Longo, Valentina, Adler, Werner, Horstmann, Jens, Schaub, Friederike, Dietlein, Thomas, Cursiefen, Claus and Heindl, Ludwig M. (2020). Analysis of peripapillary vessel density and Bruch's membrane opening-based neuroretinal rim parameters in glaucoma using OCT and OCT-angiography. Eye, 34 (6). S. 1086 - 1094. LONDON: NATURE PUBLISHING GROUP. ISSN 1476-5454

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Abstract

Purpose To compare peripapillary vessel density (VD) measured by spectral domain optical coherence tomography angiography (SD-OCT-A) with morphometric parameters assessing the neuroretinal rim based on Bruch's membrane opening (BMO) by spectral domain optical coherence tomography (SD-OCT) in glaucoma. Methods In this non-interventional cohort study, 50 eyes of 25 consecutively enrolled patients with diagnosis of glaucoma underwent SD-OCT and SD-OCT-A imaging of the optic nerve head (ONH). BMO minimum rim width (BMO-MRW) and area (BMO-MRA) as well as peripapillary retinal nerve fiber layer (RNFL) thickness were compared to peripapillary VD in the RNFL layer around the ONH. Results Mean BMO-MRW was 221.46 +/- 81.5 mu m, mean BMO-MRA was 1.05 +/- 0.04 mm(2), mean RNFL thickness was 72.46 +/- 23.16 mu m, and mean VD was 43.8 +/- 11.4%. VD was significantly lower when morphometric parameters had lower thickness values (p < 0.01). Correlation coefficients and their 95%- confidence intervals (95%-CI) with VD were r = 0.53 (95%-CI: 0.21-0.77) for BMO-MRW, r = 0.55 (95%-CI: 0.21-0.77) for BMO-MRA, and r = 0.57 (95%-CI: 0.13-0.73) for RNFL thickness. Intra-individual VD in both eyes correlated with r = 0.72 (p < 0.001), mean VD was comparable (p = 0.6). Eyes with high global RNFL thickness (>90 mu m) showed less VD variance (sigma(2) = 48.1) compared to eyes with highly reduced RNFL thickness (<65 mu m; sigma(2) = 82.0). Best corrected visual acuity, perimetric mean defect, and PSD correlated significantly with VD (95%-CI: -0.66 to -0.10, 0.16 to 0.6, and -0.65 to -0.02, respectively). Conclusions Peripapillary vessel density measured by SD-OCT angiography correlates significantly with Bruch's membrane opening-based parameters measured by SD-OCT in glaucoma patients.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Enders, Philip UNSPECIFIED orcid.org/0000-0002-9527-4957 UNSPECIFIED Longo, Valentina UNSPECIFIED UNSPECIFIED UNSPECIFIED Adler, Werner UNSPECIFIED UNSPECIFIED UNSPECIFIED Horstmann, Jens UNSPECIFIED UNSPECIFIED UNSPECIFIED Schaub, Friederike UNSPECIFIED UNSPECIFIED UNSPECIFIED Dietlein, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Cursiefen, Claus UNSPECIFIED UNSPECIFIED UNSPECIFIED Heindl, Ludwig M. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-332189
DOI:	10.1038/s41433-019-0631-8
Journal or Publication Title:	Eye
Volume:	34
Number:	6
Page Range:	S. 1086 - 1094
Date:	2020
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	1476-5454
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language INTRAOCULAR-PRESSURE MEASUREMENT; OUTFLOW; NERVE; ANGLE Multiple languages Ophthalmology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/33218