Universität zu Köln

Jansen, Lina, Merz, Maximilian, Engelhardt, Monika, Weisel, Katja, Scheid, Christof, Straka, Christian, Langer, Christian, Salwender, Hans, Einsele, Hermann, Kroege, Nikolaus, Beelen, Dietrich W., Dreger, Peter, Goldschmidt, Hartmut and Brenner, Hermann ORCID: 0000-0002-6129-1572 (2020). Autologous stem cell transplantation in multiple myeloma patients: utilization patterns and hospital effects. Leuk. Lymphoma, 61 (10). S. 2365 - 2375. ABINGDON: TAYLOR & FRANCIS LTD. ISSN 1029-2403

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Abstract

Evidence on volume outcome associations for autologous stem cell transplantation (ASCT) in multiple myeloma (MM) is limited. We investigated ASCT utilization patterns and volume outcome associations in the German National Registry for Stem Cell Transplants (DRST). MM patients with an upfront ASCT between 1998 and 2014 registered in the DRST were included. ASCT utilization increased strongly from 6% to 17% between 1999 and 2013 with the largest increase for patients aged 60-64 years (8-34%). The mean number of ASCTs conducted in the hospitals per year varied (quintiles, Q1:0.0-8.2 to Q5:31.0-102.7). Center volume was not associated with survival after upfront ASCT (lowest vs. highest center volume, hazard ratios and 95% confidence intervals: 0.95 (0.76-1.18),p = 0.92). Our findings may reflect a high standard of care and degree of specialization of centers performing ASCT for MM in Germany.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Jansen, Lina UNSPECIFIED UNSPECIFIED UNSPECIFIED Merz, Maximilian UNSPECIFIED UNSPECIFIED UNSPECIFIED Engelhardt, Monika UNSPECIFIED UNSPECIFIED UNSPECIFIED Weisel, Katja UNSPECIFIED UNSPECIFIED UNSPECIFIED Scheid, Christof UNSPECIFIED UNSPECIFIED UNSPECIFIED Straka, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Langer, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Salwender, Hans UNSPECIFIED UNSPECIFIED UNSPECIFIED Einsele, Hermann UNSPECIFIED UNSPECIFIED UNSPECIFIED Kroege, Nikolaus UNSPECIFIED UNSPECIFIED UNSPECIFIED Beelen, Dietrich W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Dreger, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Goldschmidt, Hartmut UNSPECIFIED UNSPECIFIED UNSPECIFIED Brenner, Hermann UNSPECIFIED orcid.org/0000-0002-6129-1572 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-332848
DOI:	10.1080/10428194.2020.1768383
Journal or Publication Title:	Leuk. Lymphoma
Volume:	61
Number:	10
Page Range:	S. 2365 - 2375
Date:	2020
Publisher:	TAYLOR & FRANCIS LTD
Place of Publication:	ABINGDON
ISSN:	1029-2403
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ELDERLY-PATIENTS; SURVIVAL; MORTALITY; VOLUME; ASSOCIATION; OUTCOMES Multiple languages Oncology; Hematology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/33284