Universität zu Köln

Lee, Yeong Chan ORCID: 0000-0002-2093-3161, Kang, Jae Myeong, Lee, Hyewon, Kim, Kiwon, Kim, Soyeon, Yu, Tae Yang, Lee, Eun-Mi, Kim, Clara Tammy, Kim, Doh Kwan, Lewis, Matthew ORCID: 0000-0001-7973-0716, Won, Hong-Hee, Jessen, Frank and Myung, Woojae (2020). Subjective cognitive decline and subsequent dementia: a nationwide cohort study of 579,710 people aged 66 years in South Korea. Alzheimers Res. Ther., 12 (1). LONDON: BMC. ISSN 1758-9193

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Abstract

Background Subjective cognitive decline (SCD) is a potential risk factor for dementia. We aimed to investigate the association between SCD and subsequent dementia in a nationwide population-based cohort in South Korea. Methods This cohort included 579,710 66-year-old adults who were followed for a total of 3,870,293 person-years (average 6.68 +/- 1.33 years per person). All subjects completed a questionnaire about subjective memory impairment, the Pre-screening Korean Dementia Screening Questionnaire (KDSQ-P), which included a validated 5-item derivative, and were determined to have SCD based on a single question assessing memory decline. Depressive symptoms were assessed in all subjects using a 3-item modified geriatric depression scale. Hazard ratios were estimated using the Cox proportional hazards model and compared between subjects with and without SCD. Results Compared to subjects without SCD, those with SCD were more likely to develop dementia (incidence per 1000 person-years: non-SCD, 5.66; SCD, 8.59). After adjusting for potential confounding factors, the risk of subsequent dementia significantly increased in subjects with SCD, with an adjusted hazard ratio (aHR) of 1.38 (95% confidence interval [CI] 1.34 to 1.41). The risk of subsequent dementia was greatly increased in subjects with higher KDSQ-P scores (aHR = 2.77, 95% CI 2.35 to 3.27). A significant association between SCD and dementia was observed in both depressive and non-depressive symptom groups (aHR = 1.50, 95% CI 1.42 to 1.57 in subjects with depressive symptoms; aHR = 1.33, 95% CI 1.29 to 1.37 in subjects without depressive symptoms; P = 0.001). Conclusions In this population of 66-year-old individuals, SCD was significantly associated with an increased risk of subsequent dementia. This association was found in both depressive and non-depressive groups, with an increased risk of dementia in the presence of depressive symptoms. Our findings suggest that SCD indicates a risk for dementia. Further studies are needed to delineate potential approaches to preventing the development of dementia in individuals with SCD.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Lee, Yeong Chan UNSPECIFIED orcid.org/0000-0002-2093-3161 UNSPECIFIED Kang, Jae Myeong UNSPECIFIED UNSPECIFIED UNSPECIFIED Lee, Hyewon UNSPECIFIED UNSPECIFIED UNSPECIFIED Kim, Kiwon UNSPECIFIED UNSPECIFIED UNSPECIFIED Kim, Soyeon UNSPECIFIED UNSPECIFIED UNSPECIFIED Yu, Tae Yang UNSPECIFIED UNSPECIFIED UNSPECIFIED Lee, Eun-Mi UNSPECIFIED UNSPECIFIED UNSPECIFIED Kim, Clara Tammy UNSPECIFIED UNSPECIFIED UNSPECIFIED Kim, Doh Kwan UNSPECIFIED UNSPECIFIED UNSPECIFIED Lewis, Matthew UNSPECIFIED orcid.org/0000-0001-7973-0716 UNSPECIFIED Won, Hong-Hee UNSPECIFIED UNSPECIFIED UNSPECIFIED Jessen, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Myung, Woojae UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-334314
DOI:	10.1186/s13195-020-00618-1
Journal or Publication Title:	Alzheimers Res. Ther.
Volume:	12
Number:	1
Date:	2020
Publisher:	BMC
Place of Publication:	LONDON
ISSN:	1758-9193
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MEMORY COMPLAINTS; ALZHEIMERS-DISEASE; OLDER-ADULTS; IMPAIRMENT; RISK; ASSOCIATION; PROGRESSION; PREVALENCE; DEPRESSION; FRAMEWORK Multiple languages Clinical Neurology; Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/33431