Universität zu Köln

Murji, Ally, Biberoglu, Kutay, Leng, Jinhua, Mueller, Michael D., Roemer, Thomas, Vignali, Michele and Yarmolinskaya, Maria (2020). Use of dienogest in endometriosis: a narrative literature review and expert commentary. Curr. Med. Res. Opin., 36 (5). S. 895 - 908. ABINGDON: TAYLOR & FRANCIS LTD. ISSN 1473-4877

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Abstract

Objective: Endometriosis affects up to 10% of women of reproductive age, and the main goal of treatment is to relieve symptoms. Progestins have been the mainstay of endometriosis suppression, of which dienogest has become an important option in many parts of the world. This is an expert literature review, with recommendations on the use of dienogest in the context of various clinical considerations when treating endometriosis. Methods: A search of PubMed was conducted for papers published between 2007 and 2019 on the use of dienogest in endometriosis. Experts reviewed these and included those they considered most relevant in clinical practice, according to their own clinical experience. Results: Evidence regarding the long-term use (>15 months) of dienogest for the management of endometriosis is presented, with experts concluding that the efficacy of dienogest should be assessed primarily on its impact on pain and quality of life. Fertility preservation, the option to avoid or delay surgery, and managing bleeding irregularities that can occur with this treatment are also considered. Counseling women on potential bleeding risks before starting treatment may be helpful, and evidence suggests that few women discontinue treatment for this reason, with the benefits of treatment outweighing any impact of bleeding irregularities. Conclusions: Overall, the evidence demonstrates that dienogest offers an effective and tolerable alternative or adjunct to surgery and provides many advantages over combined hormonal contraceptives for the treatment of endometriosis. It is important that treatment guidelines are followed and care is tailored to the woman's individual needs and desires.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Murji, Ally UNSPECIFIED UNSPECIFIED UNSPECIFIED Biberoglu, Kutay UNSPECIFIED UNSPECIFIED UNSPECIFIED Leng, Jinhua UNSPECIFIED UNSPECIFIED UNSPECIFIED Mueller, Michael D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Roemer, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Vignali, Michele UNSPECIFIED UNSPECIFIED UNSPECIFIED Yarmolinskaya, Maria UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-334494
DOI:	10.1080/03007995.2020.1744120
Journal or Publication Title:	Curr. Med. Res. Opin.
Volume:	36
Number:	5
Page Range:	S. 895 - 908
Date:	2020
Publisher:	TAYLOR & FRANCIS LTD
Place of Publication:	ABINGDON
ISSN:	1473-4877
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language QUALITY-OF-LIFE; DEEP INFILTRATING ENDOMETRIOSIS; UTERINE ARTERY EMBOLIZATION; HORMONE REPLACEMENT THERAPY; LONG-TERM USE; DOUBLE-BLIND; ORAL-CONTRACEPTIVES; BREAST-CANCER; PELVIC PAIN; LAPAROSCOPIC EXCISION Multiple languages Medicine, General & Internal; Medicine, Research & Experimental Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/33449