Universität zu Köln

Andrade, Pablo ORCID: 0000-0002-2596-7301, Heiden, Petra, Hoevels, Moritz, Schlamann, Marc, Baldermann, Juan C., Huys, Daniel ORCID: 0000-0002-9124-4128 and Visser-Vandewalle, Veerle (2020). Modulation of Fibers to Motor Cortex during Thalamic DBS in Tourette Patients Correlates with Tic Reduction. Brain Sci., 10 (5). BASEL: MDPI. ISSN 2076-3425

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Abstract

Probabilistic tractography in Tourette syndrome (TS) patients have shown an alteration in the connectivity of the primary motor cortex and supplementary motor area with the striatum and thalamus, suggesting an abnormal connectivity of the cortico-striatum-thalamocortical-pathways in TS. Deep brain stimulation (DBS) of the centromedian nucleus-nucleus ventrooralis internus (CM-Voi complex) in the thalamus is an effective treatment for refractory TS patients. We investigated the connectivity of activated fibers from CM-Voi to the motor cortex and its correlation between these projections and their clinical outcome. Seven patients with TS underwent CM-Voi-DBS surgery and were clinically evaluated preoperatively and six months postoperatively. We performed diffusion tensor imaging to display the activated fibers projecting from the CM-Voi to the different motor cortex regions of interest. These analyses showed that the extent of tic reduction during DBS is associated with the degree of stimulation-dependent connectivity between CM-Voi and the motor cortex, and in particular, an increased density of projections to the presupplementary motor area (preSMA). Non-responder patients displayed the largest amount of active fibers projecting into cortical areas other than motor cortex compared to responder patients. These findings support the notion that an abnormal connectivity of thalamocortical pathways underlies TS, and that modulation of these circuits through DBS could restore the function and reduce symptoms.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Andrade, Pablo UNSPECIFIED orcid.org/0000-0002-2596-7301 UNSPECIFIED Heiden, Petra UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoevels, Moritz UNSPECIFIED UNSPECIFIED UNSPECIFIED Schlamann, Marc UNSPECIFIED UNSPECIFIED UNSPECIFIED Baldermann, Juan C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Huys, Daniel UNSPECIFIED orcid.org/0000-0002-9124-4128 UNSPECIFIED Visser-Vandewalle, Veerle UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-334855
DOI:	10.3390/brainsci10050302
Journal or Publication Title:	Brain Sci.
Volume:	10
Number:	5
Date:	2020
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2076-3425
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DEEP BRAIN-STIMULATION; STRUCTURAL CONNECTIVITY; TRACTOGRAPHY; NETWORKS; CORTICES; MRI Multiple languages Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/33485