Universität zu Köln

Schoenberg, Alfrun, Hamdorf, Matthias and Bock, Felix (2020). Immunomodulatory Strategies Targeting Dendritic Cells to Improve Corneal Graft Survival. J. Clin. Med., 9 (5). BASEL: MDPI. ISSN 2077-0383

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Abstract

Even though the cornea is regarded as an immune-privileged tissue, transplantation always comes with the risk of rejection due to mismatches between donor and recipient. It is common sense that an alternative to corticosteroids as the current gold standard for treatment of corneal transplantation is needed. Since blood and lymphatic vessels have been identified as a severe risk factor for corneal allograft survival, much research has focused on vessel regression or inhibition of hem- and lymphangiogenesis in general. However, lymphatic vessels have been identified as required for the inflammation's resolution. Therefore, targeting other players of corneal engraftment could reveal new therapeutic strategies. The establishment of a tolerogenic microenvironment at the graft site would leave the recipient with the ability to manage pathogenic conditions independent from transplantation. Dendritic cells (DCs) as the central player of the immune system represent a target that allows the induction of tolerogenic mechanisms by many different strategies. These strategies are reviewed in this article with regard to their success in corneal transplantation.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schoenberg, Alfrun UNSPECIFIED UNSPECIFIED UNSPECIFIED Hamdorf, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Bock, Felix UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-334909
DOI:	10.3390/jcm9051280
Journal or Publication Title:	J. Clin. Med.
Volume:	9
Number:	5
Date:	2020
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2077-0383
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language REGULATORY T-CELLS; PROGRAMMED DEATH LIGAND-1; ALLOGRAFT-REJECTION; ADHESION MOLECULE; INDUCIBLE COSTIMULATOR; INDOLEAMINE 2,3-DIOXYGENASE; CARDIAC ALLOGRAFT; GENE-TRANSFER; MONOCLONAL-ANTIBODY; CD28 COSTIMULATION Multiple languages Medicine, General & Internal Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/33490