Nemejcova, Kristyna, Kocian, Roman, Kohler, Christhardt, Jarkovsky, Jiri, Klat, Jaroslav, Berjon, Alberto ORCID: 0000-0002-3467-106X, Pilka, Radovan, Sehnal, Borek, Gil-Ibanez, Blanca, Lupo, Ezequiel ORCID: 0000-0001-6040-3360, Petiz, Almerinda, Arencibia Sanchez, Octavio, Kascak, Peter, Martinelli, Fabio ORCID: 0000-0002-4863-1747, Buda, Alessandro, Presl, Jiri, Barahona, Marc ORCID: 0000-0002-9969-5628, van Lonkhuijzen, Luc, Szatkowski, Wiktor, Minar, Lubos, Pakiz, Maja, Havelka, Pavel, Zorrero, Cristina, Misiek, Marcin, Snyman, Leon Cornelius, Wydra, Dariusz ORCID: 0000-0002-4510-9558, Vergote, Ignace, Vinnytska, Alla, Redecha, Mikulas, Michal, Martin ORCID: 0000-0001-8580-9949, Tingulstad, Solveig, Kipp, Barbara, Szewczyk, Grzegorz, Toth, Robert, de Santiago Garcia, Francisco Javier, Coronado Martin, Pluvio Jesus, Poka, Robert ORCID: 0000-0003-1836-1579, Tamussino, Karl, Luyckx, Mathieu, Fastrez, Maxime, Carlos Staringer, Juan, Germanova, Anna, Plaikner, Andrea, Bajsova, Sylva, Dundr, Pavel, Mallmann-Gottschalk, Nina and Cibula, David (2020). Central Pathology Review in SENTIX, a Prospective Observational International Study on Sentinel Lymph Node Biopsy in Patients with Early-Stage Cervical Cancer (ENGOT-CX2). Cancers, 12 (5). BASEL: MDPI. ISSN 2072-6694

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Abstract

The quality of pathological assessment is crucial for the safety of patients with cervical cancer if pelvic lymph node dissection is to be replaced by sentinel lymph node (SLN) biopsy. Central pathology review of SLN pathological ultrastaging was conducted in the prospective SENTIX/European Network of Gynaecological Oncological Trial (ENGOT)-CX2 study. All specimens from at least two patients per site were submitted for the central review. For cases with major or critical deviations, the sites were requested to submit all samples from all additional patients for second-round assessment. From the group of 300 patients, samples from 83 cases from 37 sites were reviewed in the first round. Minor, major, critical, and no deviations were identified in 28%, 19%, 14%, and 39% of cases, respectively. Samples from 26 patients were submitted for the second-round review, with only two major deviations found. In conclusion, a high rate of major or critical deviations was identified in the first round of the central pathology review (28% of samples). This reflects a substantial heterogeneity in current practice, despite trial protocol requirements. The importance of the central review conducted prospectively at the early phase of the trial is demonstrated by a substantial improvement of SLN ultrastaging quality in the second-round review.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Nemejcova, KristynaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kocian, RomanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kohler, ChristhardtUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jarkovsky, JiriUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klat, JaroslavUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Berjon, AlbertoUNSPECIFIEDorcid.org/0000-0002-3467-106XUNSPECIFIED
Pilka, RadovanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sehnal, BorekUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gil-Ibanez, BlancaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lupo, EzequielUNSPECIFIEDorcid.org/0000-0001-6040-3360UNSPECIFIED
Petiz, AlmerindaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Arencibia Sanchez, OctavioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kascak, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Martinelli, FabioUNSPECIFIEDorcid.org/0000-0002-4863-1747UNSPECIFIED
Buda, AlessandroUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Presl, JiriUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Barahona, MarcUNSPECIFIEDorcid.org/0000-0002-9969-5628UNSPECIFIED
van Lonkhuijzen, LucUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Szatkowski, WiktorUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Minar, LubosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pakiz, MajaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Havelka, PavelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zorrero, CristinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Misiek, MarcinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Snyman, Leon CorneliusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wydra, DariuszUNSPECIFIEDorcid.org/0000-0002-4510-9558UNSPECIFIED
Vergote, IgnaceUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vinnytska, AllaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Redecha, MikulasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Michal, MartinUNSPECIFIEDorcid.org/0000-0001-8580-9949UNSPECIFIED
Tingulstad, SolveigUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kipp, BarbaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Szewczyk, GrzegorzUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Toth, RobertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
de Santiago Garcia, Francisco JavierUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Coronado Martin, Pluvio JesusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Poka, RobertUNSPECIFIEDorcid.org/0000-0003-1836-1579UNSPECIFIED
Tamussino, KarlUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Luyckx, MathieuUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fastrez, MaximeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Carlos Staringer, JuanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Germanova, AnnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Plaikner, AndreaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bajsova, SylvaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dundr, PavelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mallmann-Gottschalk, NinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cibula, DavidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-334923
DOI: 10.3390/cancers12051115
Journal or Publication Title: Cancers
Volume: 12
Number: 5
Date: 2020
Publisher: MDPI
Place of Publication: BASEL
ISSN: 2072-6694
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
INDOCYANINE GREEN; UTERINE; SURGERY; LYMPHADENECTOMY; FLUORESCENCE; METASTASIS; PREVALENCE; MANAGEMENT; OUTCOMES; DISEASEMultiple languages
OncologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/33492

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