Universität zu Köln

Schueller, Thomas, Fischer, Adrian G., Gruendler, Theo O. J., Baldermann, Juan Carlos, Huys, Daniel ORCID: 0000-0002-9124-4128, Ullsperger, Markus and Kuhn, Jens (2020). Decreased transfer of value to action in Tourette syndrome. Cortex, 126. S. 39 - 49. PARIS: ELSEVIER MASSON, CORP OFF. ISSN 1973-8102

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Abstract

Objective: Tourette syndrome is a neurodevelopmental disorder putatively associated with a hyperdopaminergic state. Therefore, it seems plausible that excessive dopamine transmission in Tourette syndrome alters the ability to learn based on rewards and punishments. We tested whether Tourette syndrome patients exhibited altered reinforcement learning and corresponding feedback-related EEG deflections. Methods: We used a reinforcement learning task providing factual and counterfactual feedback in a sample of 15 Tourette syndrome patients and matched healthy controls whilst recording EEG. The paradigm presented various reward probabilities to enforce adaptive adjustments. We employed a computational model to derive estimates of the prediction error, which we used for single-trial regression analysis of the EEG data. Results: We found that Tourette syndrome patients showed increased choice stochasticity compared to controls. The feedback-related negativity represented an axiomatic prediction error for factual feedback and did not differ between groups. We observed attenuated P3a modulation specifically for factual feedback in Tourette syndrome patients, representing impaired coding of attention allocation. Conclusion: Our findings indicate that cortical prediction error coding is unaffected by Tourette syndrome. Nonetheless, the transfer of learned values into choice formation is degraded, in line with a hyperdopaminergic state. (C) 2020 Elsevier Ltd. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schueller, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Fischer, Adrian G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gruendler, Theo O. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Baldermann, Juan Carlos UNSPECIFIED UNSPECIFIED UNSPECIFIED Huys, Daniel UNSPECIFIED orcid.org/0000-0002-9124-4128 UNSPECIFIED Ullsperger, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED Kuhn, Jens UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-335941
DOI:	10.1016/j.cortex.2019.12.027
Journal or Publication Title:	Cortex
Volume:	126
Page Range:	S. 39 - 49
Date:	2020
Publisher:	ELSEVIER MASSON, CORP OFF
Place of Publication:	PARIS
ISSN:	1973-8102
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language YOUNG-PEOPLE; REWARD; MODULATION; UPDATE; PARKINSONS; DISORDERS; DOPAMINE; LEVODOPA Multiple languages Behavioral Sciences; Neurosciences; Psychology, Experimental Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/33594