Groeschel, Matthias I., Meehan, Conor J., Barilar, Ivan ORCID: 0000-0002-4789-2777, Diricks, Margo ORCID: 0000-0002-5428-1456, Gonzaga, Aitor, Steglich, Matthias, Conchillo-Sole, Oscar ORCID: 0000-0003-4266-246X, Scherer, Isabell-Christin, Mamat, Uwe, Luz, Christian F., De Bruyne, Katrien, Utpatel, Christian, Yero, Daniel ORCID: 0000-0002-6234-4082, Gibert, Isidre ORCID: 0000-0003-1442-2258, Daura, Xavier, Kampmeier, Stefanie, Rahman, Nurdyana Abdul, Kresken, Michael, van der Werf, Tjip S., Alio, Ifey, Streit, Wolfgang R., Zhou, Kai, Schwartz, Thomas, Rossen, John W. A., Farhat, Maha R., Schaible, Ulrich E., Nuebel, Ulrich, Rupp, Jan, Steinmann, Joerg, Niemann, Stefan ORCID: 0000-0002-6604-0684 and Kohl, Thomas A. (2020). The phylogenetic landscape and nosocomial spread of the multidrug-resistant opportunist Stenotrophomonas maltophilia. Nat. Commun., 11 (1). LONDON: NATURE PUBLISHING GROUP. ISSN 2041-1723

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Abstract

Recent studies portend a rising global spread and adaptation of human- or healthcare-associated pathogens. Here, we analyse an international collection of the emerging, multidrug-resistant, opportunistic pathogen Stenotrophomonas maltophilia from 22 countries to infer population structure and clonality at a global level. We show that the S. maltophilia complex is divided into 23 monophyletic lineages, most of which harbour strains of all degrees of human virulence. Lineage Sm6 comprises the highest rate of human-associated strains, linked to key virulence and resistance genes. Transmission analysis identifies potential outbreak events of genetically closely related strains isolated within days or weeks in the same hospitals. Multidrug resistance of the opportunistic pathogen Stenotrophomonas maltophilia is an increasing problem. Here, analyzing strains from 22 countries, the authors show that the S. maltophilia complex is divided into 23 monophyletic lineages and find evidence for intra-hospital transmission.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Groeschel, Matthias I.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meehan, Conor J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Barilar, IvanUNSPECIFIEDorcid.org/0000-0002-4789-2777UNSPECIFIED
Diricks, MargoUNSPECIFIEDorcid.org/0000-0002-5428-1456UNSPECIFIED
Gonzaga, AitorUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Steglich, MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Conchillo-Sole, OscarUNSPECIFIEDorcid.org/0000-0003-4266-246XUNSPECIFIED
Scherer, Isabell-ChristinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mamat, UweUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Luz, Christian F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
De Bruyne, KatrienUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Utpatel, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yero, DanielUNSPECIFIEDorcid.org/0000-0002-6234-4082UNSPECIFIED
Gibert, IsidreUNSPECIFIEDorcid.org/0000-0003-1442-2258UNSPECIFIED
Daura, XavierUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kampmeier, StefanieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rahman, Nurdyana AbdulUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kresken, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van der Werf, Tjip S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Alio, IfeyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Streit, Wolfgang R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zhou, KaiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schwartz, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rossen, John W. A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Farhat, Maha R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schaible, Ulrich E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nuebel, UlrichUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rupp, JanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Steinmann, JoergUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Niemann, StefanUNSPECIFIEDorcid.org/0000-0002-6604-0684UNSPECIFIED
Kohl, Thomas A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-336377
DOI: 10.1038/s41467-020-15123-0
Journal or Publication Title: Nat. Commun.
Volume: 11
Number: 1
Date: 2020
Publisher: NATURE PUBLISHING GROUP
Place of Publication: LONDON
ISSN: 2041-1723
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
SEQUENCE TYPING SCHEME; INFECTIONS; ANNOTATION; DISEASE; PROTEIN; TREE; TOOLMultiple languages
Multidisciplinary SciencesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/33637

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