Universität zu Köln

Goody, Philip Roger, Hosen, Mohammed Rabiul, Christmann, Dominik, Niepmann, Sven Thomas, Zietzer, Andreas, Adam, Matti ORCID: 0000-0002-6990-8135, Boenner, Florian, Zimmer, Sebastian, Nickenig, Georg and Jansen, Felix (2020). Aortic Valve Stenosis From Basic Mechanisms to Novel Therapeutic Targets. Arterioscler. Thromb. Vasc. Biol., 40 (4). S. 885 - 901. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 1524-4636

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Abstract

Aortic valve stenosis is the most prevalent heart valve disease worldwide. Although interventional treatment options have rapidly improved in recent years, symptomatic aortic valve stenosis is still associated with high morbidity and mortality. Calcific aortic valve stenosis is characterized by a progressive fibro-calcific remodeling and thickening of the aortic valve cusps, which subsequently leads to valve obstruction. The underlying pathophysiology is complex and involves endothelial dysfunction, immune cell infiltration, myofibroblastic and osteoblastic differentiation, and, subsequently, calcification. To date, no pharmacotherapy has been established to prevent aortic valve calcification. However, novel promising therapeutic targets have been recently identified. This review summarizes the current knowledge of pathomechanisms involved in aortic valve calcification and points out novel treatment strategies.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Goody, Philip Roger UNSPECIFIED UNSPECIFIED UNSPECIFIED Hosen, Mohammed Rabiul UNSPECIFIED UNSPECIFIED UNSPECIFIED Christmann, Dominik UNSPECIFIED UNSPECIFIED UNSPECIFIED Niepmann, Sven Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Zietzer, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Adam, Matti UNSPECIFIED orcid.org/0000-0002-6990-8135 UNSPECIFIED Boenner, Florian UNSPECIFIED UNSPECIFIED UNSPECIFIED Zimmer, Sebastian UNSPECIFIED UNSPECIFIED UNSPECIFIED Nickenig, Georg UNSPECIFIED UNSPECIFIED UNSPECIFIED Jansen, Felix UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-338796
DOI:	10.1161/ATVBAHA.119.313067
Journal or Publication Title:	Arterioscler. Thromb. Vasc. Biol.
Volume:	40
Number:	4
Page Range:	S. 885 - 901
Date:	2020
Publisher:	LIPPINCOTT WILLIAMS & WILKINS
Place of Publication:	PHILADELPHIA
ISSN:	1524-4636
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language VALVULAR INTERSTITIAL-CELLS; PROMOTE OSTEOBLAST DIFFERENTIATION; ENDOTHELIAL GROWTH-FACTOR; LOW-DENSITY-LIPOPROTEIN; VASCULAR CALCIFICATION; OSTEOCLAST DIFFERENTIATION; OSTEOGENIC PHENOTYPE; OXIDATIVE STRESS; CLINICAL FACTORS; MATRIX VESICLES Multiple languages Hematology; Peripheral Vascular Disease Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/33879